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中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (7): 778-785.doi: 10.12092/j.issn.1009-2501.2019.07.009

• 基础研究 • 上一篇    下一篇

某三级医院常见细菌耐药性与抗菌药物使用相关性分析

盛雪鹤,许锦英,王幼林,殷 勤   

  1. 皖南医学院第二附属医院药剂科,芜湖 241000,安徽
  • 收稿日期:2019-01-29 修回日期:2019-02-14 出版日期:2019-07-26 发布日期:2019-07-29
  • 通讯作者: 殷勤,男,硕士研究生,主任药师,研究方向:药事管理、临床药学、药物经济学。 Tel:13905530299 E-mail:yq0553@163.com
  • 作者简介:盛雪鹤,男,本科,主管药师,研究方向:临床药学、药事管理。 Tel:15155384983 E-mail:20332458@qq.com
  • 基金资助:

    皖南医学院重点科研项目培育基金项目(WK2017ZF13)

Correlation analysis of common bacterial resistance and antimicrobial use in a tertiary hospital

SHENG Xuehe,XU Jinying,WANG Youlin,YIN Qin   

  1. Department of Pharmacy, the Second Affiliated Hospital of Wannan Medical College, Wuhu 241000, Anhui, China
  • Received:2019-01-29 Revised:2019-02-14 Online:2019-07-26 Published:2019-07-29

摘要:

目的:通过调查抗菌药物使用量与细菌耐药性之间相关性,为临床合理使用抗菌药物提供参考依据。方法:调查统计该院2012-2017年常用抗菌药物使用量与临床标本分离细菌的耐药率,利用SPSS 20.0软件进行统计分析。结果: 该院常见革兰氏阴性菌中,大肠埃希菌耐药率与阿米卡星和亚胺培南的DDDs相关,相关系数分别为r=-0.957(P=0.011),r=0.881(P=0.048),肺炎克雷伯耐药率与亚胺培南的DDDs相关,相关系数为r=0.949(P=0.014);革兰氏阳性菌中,溶血性葡萄球菌耐药率与左氧氟沙星的DDDs相关,相关系数为r=0.975(P=0.025)。结论:抗菌药物使用量与细菌耐药性存在相关性,临床应根据药敏实验结果选择合适的抗菌药物,避免细菌耐药。

关键词: 抗菌药物, 细菌耐药, 相关性, 药敏实验

Abstract:

AIM: To investigate the correlation between antimicrobial drug use and bacterial drug resistance, and to provide reference basis for clinical rational use of antimicrobial drugs. METHODS: The usage of commonly used antibacterial drugs and the drug resistance rate of bacteria isolated from clinical specimens in the hospital from 2012 to 2017 were investigated and statistically analyzed using SPSS 20.0 software.RESULTS:Among the common gram-negative bacteria in the hospital, the drug resistance rate of escherichia coli was correlated with DDDs of amikacin and imipenem (r=-0.957,P=0.011) and r=0.881 (P=0.048), respectively. The drug resistance rate of klebsiella pneumoniae was correlated with DDDs of imipenem (r=0.949,P=0.014).Among gram-positive bacteria, the drug resistance rate of staphylococcus haemolyticus was correlated with DDDs of levofloxacin, and the correlation coefficient was r=0.975 (P=0.025).CONCLUSION: There is a correlation between the amount of antimicrobial drugs and bacterial drug resistance.

Key words: antimicrobial agents, bacterial resistance, correlation, drug sensitive experiment

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