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中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (5): 589-594.doi: 10.12092/j.issn.1009-2501.2019.05.017

• 综述与讲座 • 上一篇    下一篇

高尿酸血症药物治疗研究进展

孙珊珊1,2,曲连悦1,2,杜荣蓉1,2,林建阳1,2   

  1. 1中国医科大学附属第一医院药学部,沈阳 110001,辽宁;2中国医科大学药学院,沈阳 110122,辽宁
  • 收稿日期:2018-12-03 修回日期:2019-02-20 出版日期:2019-05-26 发布日期:2019-05-28
  • 通讯作者: 林建阳,女,教授、主任药师,博士生导师,主要研究方向:临床前药代动力学和药物质量评价。 E-mail: linjianyang3@126.com
  • 作者简介:孙珊珊,女,硕士在读,研究方向:临床药学。 Tel:024-83282662 E-mail: 18840827936@163.com
  • 基金资助:

    国家自然基金青年科学基金项目(81302841);辽宁省高等学校优秀人才支持计划(LJQ2014086)

Research progress on drug therapy of hyperuricemia

SUN Shanshan 1,2, QU Lianyue 1,2, DU Rongrong 1,2, LIN Jianyang 1,2   

  1. 1 Department of Pharmacy, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China; 2 College of Pharmaceutical Science, China Medical University, Shenyang 110122, Liaoning, China
  • Received:2018-12-03 Revised:2019-02-20 Online:2019-05-26 Published:2019-05-28

摘要:

高尿酸血症(hyperuricemia,HUA)是由于体内尿酸生成过多或尿酸排泄减少所致的代谢性疾病。慢性HUA和痛风与高血压、心血管疾病和慢性肾脏疾病(chronic kidney disease,CKD)等合并症密切相关。及时有效地进行降尿酸治疗(urate lowering therapy,ULT)是减少尿酸盐沉积、预防痛风发作、减轻对肾脏损害、减少其他伴随疾病发生的关键。根据药物作用靶点的不同将降尿酸药物主要分为抑制尿酸生成的药物、促进尿酸排泄的药物、促进尿酸溶解的药物以及最新发现的可同时抑制尿酸生成和促进排泄的药物四大类。近年来,新药的开发,药物的引进以及药物的联合应用已成为热点。本文就近年来降尿酸药物的研究进展进行综述。

关键词: 高尿酸血症, 药物治疗, 研究进展

Abstract:

Hyperuricemia (HUA) is a metabolic disease resulting from either the overproduction of uric acid or reduced uric acid excretion. Chronic hyperuricemia and gout are associated with comorbidities such as hypertension, cardiovascular disease and chronic kidney disease (CKD). Timely and effective urate lowering therapy (ULT) is the key to reducing urate deposition, preventing gout attacks, reducing kidney damage, and reducing the incidence of other accompanying diseases. According to the different targets of drugs, uric acid lowering drugs can be divided into four categories: drugs that inhibit the production of uric acid, drugs that promote the excretion of uric acid, drugs that promote the dissolution of uric acid, and newly discovered drugs that can simultaneously inhibit the production of uric acid and promote the excretion of uric acid. Recently the development of the promising drugs, the introduction of drugs and the combination therapy have become the research focus.This paper reviews the research progress of uric acid-lowering drugs in recent years.

Key words: hyperuricemia, drug therapy, research progress

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