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中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (8): 928-932.doi: 10.12092/j.issn.1009-2501.2019.08.013

• 药物治疗学 • 上一篇    下一篇

盐酸羟考酮对烟雾病血管重建术患者全麻苏醒期恢复质量的影响

朱冰青,韩明明,翟明玉,杨 佳,李 娟   

  1. 中国科学技术大学附属第一医院麻醉科,合肥 230036,安徽
  • 收稿日期:2019-06-18 修回日期:2019-07-21 出版日期:2019-08-26 发布日期:2019-08-30
  • 通讯作者: 李娟,女,教授,主任医师,博士生导师,研究方向:围术期脏器保护。 Tel:0551-62282671 E-mail: huamuzi1999@126.com
  • 作者简介:朱冰青,女,硕士研究生,住院医师,研究方向:围术期脏器保护。 Tel:13696772833 E-mail:zhubqmedical@163.com
  • 基金资助:

    安徽省自然科学基金项目(1908085MH251)

Effects of oxycodone hydrochloride on anesthesia recovery quality in surgical revascularization for moyamoya disease

ZHU Bingqing, HAN Mingming, ZHAI Mingyu, YANG Jia, LI Juan   

  1. Department of Anesthesiology, the First Affliated Hospital of USTC, Hefei 230036, Anhui, China
  • Received:2019-06-18 Revised:2019-07-21 Online:2019-08-26 Published:2019-08-30

摘要:

目的:比较羟考酮和舒芬太尼对缺血型烟雾病患者血管重建术后麻醉苏醒期患者恢复质量的影响。方法:选择择期行血管重建术的缺血型烟雾病患者52例,按随机数字表法分为羟考酮组和舒芬太尼组,每组26例。于手术进行到颞肌贴敷前即刻,分别给与羟考酮组、 舒芬太尼组患者0.1 mg/kg羟考酮、0.1 μg/kg舒芬太尼,术毕转入麻醉复苏室(PACU)。比较两组患者定向力恢复时间、气管导管拔出时间及在PACU停留时间;比较患者在麻醉前和PACU期间不同时点的平均动脉压(MAP)、心率 (HR);比较患者恢复定向力后10 min疼痛VAS评分及术毕30 min的Ramsay镇静评分;比较患者麻醉苏醒期间呼吸抑制、拔管呛咳、恶心呕吐、不良记忆的发生情况。结果:羟考酮组患者定向力恢复、气管导管拔出以及PACU停留时间均短于舒芬太尼组患者(P<0.05),但两组患者定向力恢复后10 min疼痛 VAS评分、术毕30 min的Ramsay评分以及各时点MAP、HR均无统计学差异。羟考酮组患者拔管后呼吸抑制率、术后恶心呕吐率较舒芬太尼组低(P<0.05),而拔管呛咳、不良记忆等事件发生率无统计学差异。结论:羟考酮可有效应用于缺血型烟雾病患者血管重建术的术后镇痛;与舒芬太尼相比,使用羟考酮术后镇痛可减少麻醉苏醒期呼吸抑制及恶心呕吐发生,提高烟雾病患者麻醉苏醒期恢复质量。

关键词: 羟考酮, 舒芬太尼, 烟雾病, 血管重建术, 麻醉苏醒期

Abstract:

AIM: To evaluate the effects of oxycodone hydrochloride and sufentanil citrate on anesthesia recovery quality in surgical revascularization for ischemic moyamoya disease. METHODS: According to the random number table, fifty-two patients of ischemic moyamoya disease scheduled for surgical revascularization were divided into two groups: oxycodone hydrochloride group (group oxycodone) and sufentanil citrate group (group sufentanil), with 26 cases in each group. When the temporal muscle was ready to be stuck, oxycodone 0.1 mg/kg was injected in group oxycodone and sufentanil 0.1 μg/kg was injected in group sufentanil. At the end of the surgery, the patient were transferred to the PACU.The extubation time, orientation recovery time, PACU stay time were recorded. Mean arterial pressure (MAP) , heart rate (HR) of all patients were recorded at preoperatively and postoperatively different time points. The VAS scores 10 minutes after orientation recovery ,the Ramsay scores 30 minutes after surgery and the incidence of postoperative complications were recorded. RESULTS:Compared with group sufentanil, the extubation time, orientation recovery time, PACU stay time were shorter in group oxycodone(P<0.05); the incidence of respiratory depression , nansea and vominiting were lower in group oxycodone(P<0.05).While there was no statistical difference in VAS scores 10 minutes after orientation recovery , Ramsay scores 30 minutes after surgery, hemodynamic parameters at different time points and the incidence of other postoperative complication between the two groups. CONCLUSION:Compared with sufentanil, the use of oxycodone can achieve effective analgesic effect and decrease the incidence of respiratory depression and nansea and vominting, enhance the post-anesthesia recovery quality in patients under surgical revascularization for ischemic moyamoya disease.

Key words: oxycodone, sufentanil, moyamoya disease, surgical revascularization, anesthesia recovery period

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