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中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (2): 184-189.

• 药物治疗学 • 上一篇    下一篇

奥拉西坦联合复方苁蓉益智胶囊治疗脑白质疏松认知障碍的临床效果观察

宋秀娟1,林永坚1,王丽娜1,徐惠琴2,刘小利3   

  1. 1 温州市第七人民医院康复精神科,温州325025,浙江; 2 温州医科大学附属第一医院神内一科,温州 325025,浙江; 3 浙江医院神内科,杭州 310030,浙江
  • 收稿日期:2016-11-09 修回日期:2017-02-06 出版日期:2017-02-26 发布日期:2017-03-02
  • 作者简介:宋秀娟,女,本科,副主任医师,研究方向:神经系统疾病所致精神障碍。 Tel: 18157760170 E-mail: dhd1027@163.com
  • 基金资助:

    浙江省医药卫生一般研究计划(2012KYB001)

Effect of oxiracetam combined with Cistanche yizhi capsule in treating cognitive disorder from leukoaraiosis

SONG Xiujuan 1,LIN Yongjian 1,WANG Lina 1,XU Huiqin 2,LIU Xiaoli 3   

  1. 1 Department of Psychiatric Rehabilitation, the Seventh People's Hospital of Wenzhou, 2 Department of Neurology, the First Affiliated Hospital of Wenzhou Medical Hospital, Wenzhou 325025, Zhejiang, China; 3 Department of Neurology, Zhejiang Hospital, Hangzhou 310030, Zhejiang, China
  • Received:2016-11-09 Revised:2017-02-06 Online:2017-02-26 Published:2017-03-02

摘要:

目的:观察奥拉西坦联合复方苁蓉益智胶囊治疗脑白质疏松认知障碍的疗效并探讨其联合治疗作用机制。方法: 将温州市第七人民医院从2013年5月至2015年5月由急诊及神经内科普通门诊收治到康复精神科的严格依照诊断标准判定为脑白质疏松认知功能障碍的94例患者随机分为试验组、对照组,每组各47例。对照组予以奥拉西坦胶囊,800 mg,3 次/d。试验组予以奥拉西坦胶囊与复方苁蓉益智胶囊合用:奥拉西坦胶囊,800 mg,3 次/d;复方苁蓉益智胶囊,1.2 g,3 次/d。温水冲服,连续服用12周。分别在患者入院第1天、出院当天、出院后3个月、出院后6个月通过随访对患者认知功能、日常生活能力、社会功能活动能力、精神状态进行测评。结果: 两组认知功能比较:经药物干预后,出院当天、随访3个月、随访6个月时统计的数值试验组优于对照组,差异具有统计学意义(P<0.05);两组日常生活能力比较:随访6个月时统计的数值试验组优于对照组,差异具有统计学意义(P<0.05);两组社会功能活动能力比较:经药物干预出院后,随访3个月、随访6个月时统计的数值试验组优于对照组,差异具有统计学意义(P<0.05);两组精神状态比较:经药物干预后,出院当天、随访3个月、随访6个月时统计的数值试验组优于对照组,差异具有统计学意义(P<0.05)。结论:在奥拉西坦的基础上联合运用复方苁蓉益智胶囊可明显改善患者认知功能、日常生活能力、社会功能活动能力、精神状态,对减少不可逆性老年性血管痴呆的发生具有重要意义,改善患者生活质量,值得临床深入推广。

关键词: 奥拉西坦, 复方苁蓉益智胶囊, 脑白质疏松, 认知功能障碍, 临床疗效

Abstract:

AIM: To observe the therapeutic effect of oxiracetam combined with Cistanche yizhi capsule on the cognitive impairment of leukoaraiosis and to explore the mechanism of its combination therapy.  METHODS: From May 2013 to May 2015, 94 patients with acute leukoaraiosis admitted from the general outpatient and neurology department to our department were randomly divided into experiment group and control group. According to the diagnostic criteria, The control group were treated with oxiracetam capsule, 800 mg, tid; the test group to be combined with oral Cetan capsule and Cistanche yizhi capsule combination: Olaxetan capsule, 800 mg, tid; Cistanche compound pills, 1.2 g , tid. Warm water blunt, taking 12 weeks. The patients' cognitive function, daily living ability, social function and mental state were evaluated on the first day of hospital admission, the day of discharge, the third month after discharge and the six months after discharge. RESULTS:The comparison of cognitive function between the two groups was statistically significant (P<0.05) after the drug intervention, the day of discharge, the follow-up of three months, the follow-up of six months, the numerical test group was better than the control group. The numerical test group was superior to the control group at the time of 6 months follow-up, the difference was statistically significant (P<0.05); compared with the control group, there was significant difference between the two groups (P<0.05). After three months of follow-up, the data of the experiment group were better than the control group. The mental status of the two groups was statistically significant (P<0.05) after the drug intervention, the day of discharge, the follow-up of three months, the follow-up of six months of experiment group was better than the control group. CONCLUSION:The combination of Oxiracetam with Cistanche yizhi capsule can improve cognitive function, daily living ability, social function and mental state, and it shows better effect in reducing the irreversibility. The occurrence of senile vascular dementia is of great significance to improve the quality of life of patients, it is worthy of clinical in-depth promotion.

Key words: oral cortisone, compound Cistanche yizhi capsule, leukoaraiosis, cognitive dysfunction, clinical curative effect

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