关键词: : 脐血, 铅, 新生儿, 端粒长度

Abstract: Objective To investigate the relationship between lead low-level exposure and telomere length in neonates. Methods A total of 97 neonates who had lower umbilical cord blood lead levels than 100 μg/L were included in this study, which were divided into two groups(group A and group B)according to the lead levels of umbilical cord blood at 50 μg/L.The lead levels of group A was <50 μg/L, and group B was ≥50 μg/L.Blood lead content was determined by atomic absorption spectrophotometry.The relative telomere length of leukocytes was evaluated by a real time fluorescence quantitative polymerase chain reaction (PCR). Results There were 68 cases in the group A and 29 cases in the group B.Group B had shorter telomere lengths than group A (0.536±0.476 VS 0.803±0.568), which was negatively correlated with blood lead levels (r=-0.303, P=0.003).There was significant difference of telomere length between two groups(t=2.222, P=0.029). Conclusions The telomere length in neonate was associated with a higher umbilical cord blood lead levels.Lead low-level exposure may contribute to shorten the neonatal telomere length.

Key words: cord blood, lead, neonates, telomere length