关键词: 低出生体重, 谷胱甘肽s转移酶, 基因多态性

Abstract: Objective To investigate the relationship between umbilical cord blood glutathione S-transferase (GST) M1,T1 genetic polymorphism in the Urumqi Uygur and Han newborns with low birth weight. Methods By 1∶3 matched case-control study methods,umbilical cord blood were collected and DNA was extracted,GSTM1,GSTT1 gene polymorphism were analyzed using multiple allele specific polymerase chain reaction (PCR) method. Results The genotype of GSTM1 deletion was 60.5%,the genotype of GSTT1 deletion was 5%,and the frequency of GSTM1 and GSTT1 deletion genotypes was 3.5%.The difference of genotype deletion frequency of GSTT1 in cord blood was statistically significant between the low birth weight and normal infants (P<0.05).The frequency of GSTT1 genotype was significantly different between normal and low birth weight in Uygur nationality (P<0.05).The distribution difference of Uygur normal birth weight and low birth weight infants in the different genotype frequency composition had statistical significance (P<0.05). Conclusion GSTT1 gene deletion in umbilical cord blood may increase the incidence of low birth weight,and also increase the Uygur neonates with low birth weight.The absence of GSTM1 genotype in cord blood may not affect the occurrence of low birth weight.There are differences in the distribution of different birth weight among the Uygur newborns with different birth weight.So we should understand the cause of the low birth weight,so as to improve the birth quality of the newborn.

Key words: low birth weight, glutathione s-transferase enzyme, gene polymorphism