母源性吸烟对新生儿出生体重、头围、身长及储存铁影响的研究

doi:10.11852/zgetbjzz2017-25-06-21

中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (6): 611-614.DOI: 10.11852/zgetbjzz2017-25-06-21

母源性吸烟对新生儿出生体重、头围、身长及储存铁影响的研究

张旭光¹, 袁晶², 张为伟³, 张冬梅⁴, 彭志晴⁵, 陈彦平^{1, 4}

1 哈尔滨市儿童医院临床营养科, 黑龙江哈尔滨 150010;
2 哈尔滨医科大学附属第一医院妇产科, 黑龙江哈尔滨 150001;
3 哈尔滨市儿童医院血液内科,黑龙江哈尔滨 150001;
4 哈尔滨市儿童医院儿童保健科,黑龙江哈尔滨 150010;
5 解放军总医院海南分院保健一科,海南三亚 572000

收稿日期:2016-08-13 发布日期:2017-06-10 出版日期:2017-06-10
通讯作者: 陈彦平,E-mail:15546176033@163.com
作者简介:张旭光(1984-),男,住院医师,临床医学学士,预防医学博士,主要研究方向为营养与疾病相关性的研究。
基金资助:
哈尔滨市儿研所种子基金(HEY201401)

Effect of maternal cigarette smoking on birth weight,head circumference,birth length and iron stores in newborn

ZHANG Xu-guang¹, YUAN Jing², ZHANG Wei-wei³, ZHANG Dong-mei⁴, PENG Zhi-qing⁵, CHEN Yan-ping^{1, 4}

1 Department of Clinical Nutrition,Harbin Children's Hospital,Harbin,Heilongjiang 150010,China;
2 Department of Gynaecology and Obstetrics,the First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001, China;
3 Department of Internal Medicine,Hematology and Oncology,Harbin Children's Hospital,Harbin,Heilongjiang 150010,China;
4 Department of Children's Health Care,Harbin Children's Hospital,Harbin,Heilongjiang 150010,China;
5 Department of Health Care,Hainan Branch of Chinese PLA General Hospital,Sanya,Hainan 572000,China

Received:2016-08-13 Online:2017-06-10 Published:2017-06-10
Contact: CHEN Yan-ping,E-mail:15546176033@163.com

摘要/Abstract

摘要： 目的探讨母源性吸烟对新生儿出生体重、头围、身长及储存铁的影响,为提高我国围产保健水平提供理论依据。方法以150名产妇及其新生儿为研究对象,按WHO推荐的吸烟频率分类将产妇分为不吸烟组,偶尔吸烟组以及每日吸烟组,于孕晚期进行膳食调查,计算其每日铁摄入量。测量新生儿的出生体重、身长、头围,并采集产妇外周血及新生儿脐带血,检测血清铁蛋白(SF)及血清可溶性转铁蛋白受体(sTfR)水平,计算全身铁(TBI)水平。结果产妇在孕晚期的每日铁摄入量差异无统计学意义;不吸烟组新生儿出生体重明显高于两个吸烟组(P均<0.05);两个吸烟组新生儿的头围及身长差异无统计学意义(P均>0.05);不吸烟组产妇sTfR水平明显高于两个吸烟组(P均<0.001),SF和TBI水平均低于两个吸烟组(P均<0.05);不吸烟组新生儿sTfR水平明显低于两个吸烟组(P均<0.001),SF和TBI水平明显高于两个吸烟组(P均<0.001)。结论母源性吸烟可引起产妇自身储存铁升高,而使新生儿出生体重以及储存铁降低。

关键词: 母源性吸烟, 新生儿, 铁缺乏, 全身铁

Abstract: Objective To investigate the effect of maternal cigarette smoking on birth weight,head circumference birth length and iron stores in newborn to confirm the harm of smoking behavior in pregnancy,and to provide theoretical basis for improving the level of perinatal health care in China. Methods Totally 150 puerperas and their newborns were recruited.According to the WHO definition of cigarette smoking frequency,puerperas were divided into no smoking group,occasional smoking group and daily smoking group.Daily iron intake was assessed by dietary survey in every puerpera at late pregnancy.Birth weight,head circumference and birth length of newborns were measured.Serum ferritin (SF) and soluble transferrin receptor (sTfR) levels were analyzed in maternal peripheral blood and infant cord blood at the time of delivery.Then the levels of total body iron (TBI) were calculated. Results Birth weight of newborns in no smoking group was significantly higher than that of both two smoking group (all P<0.05).There was no significant difference in average head circumference and birth length of newborns in three groups (all P>0.05).The level of sTfR was significantly higher in puerperas of no smoking group than that of two smoking groups (all P<0.001).The levels of SF and TBI were significantly lower in puerperas of no smoking group than those of two smoking groups (all P<0.05).The sTfR of newborns in no smoking group was significantly lower than that of two smoking groups (all P<0.001).The levels of SF and TBI were significantly higher in newborns of no smoking group than those of two smoking groups (all P<0.001). Conclusion Maternal cigarette smoking is associated with higher iron stores in puerperal,as well as lower birth weight and iron stores in newborn.

Key words: maternal cigarette smoking, newborn, iron deficiency, total body iron

中图分类号:

R179

张旭光, 袁晶, 张为伟, 张冬梅, 彭志晴, 陈彦平. 母源性吸烟对新生儿出生体重、头围、身长及储存铁影响的研究[J]. 中国儿童保健杂志, 2017, 25(6): 611-614.

ZHANG Xu-guang, YUAN Jing, ZHANG Wei-wei, ZHANG Dong-mei, PENG Zhi-qing, CHEN Yan-ping. Effect of maternal cigarette smoking on birth weight,head circumference,birth length and iron stores in newborn[J]. journal1, 2017, 25(6): 611-614.

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母源性吸烟对新生儿出生体重、头围、身长及储存铁影响的研究

Effect of maternal cigarette smoking on birth weight,head circumference,birth length and iron stores in newborn

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