中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (7): 687-691.DOI: 10.11852/zgetbjzz2017-25-07-11

• 综述与讲座 • 上一篇    下一篇

妊娠期糖尿病对子代健康的影响:代谢综合征的传递

霍亭竹1, 罗小丽2, 毛萌3   

  1. 1 成都市妇女儿童中心医院儿童保健指导中心,四川 成都 610091;
    2 成都市妇女儿童 中心医院儿童重症医学科,四川 成都 610091;
    3 四川大学华西第二医院儿科,四川 成都 610041
  • 收稿日期:2017-04-13 出版日期:2017-07-10 发布日期:2017-07-10
  • 通讯作者: 毛萌,E-mail:dffmmao@126.com
  • 作者简介:霍亭竹(1987-),女,重庆人,住院医师,硕士学位,主要从事儿童保健、发育行为儿科。

Effects of gestational diabetes mellitus on offspring`s health:transmission of metabolic syndrome

HUO Ting-zhu1, LUO Xiao-li2, MAO Meng3   

  1. 1 Department of Children's Health Care,Chengdu Women's and Children's Central Hospital,Chengdu,Sichuan 610091,China;
    2 Department of Pediatric Intensive Care Unit,Chengdu Women's and Children's Central Hospital,Chengdu,Sichuan 610091,China;
    3 West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,China
  • Received:2017-04-13 Online:2017-07-10 Published:2017-07-10
  • Contact: MAO Meng,E-mail:dffmmao@126.com
  • Supported by:
    “十一五”国家科技支撑计划课题(2009BAI80B00)

摘要: 妊娠期糖尿病对孕母和子代都会产生不良影响,母亲远期发生代谢综合征的风险已被证实,而其后代易发生巨大儿、大于胎龄儿,增加儿童肥胖的发病风险,罹患代谢综合征的风险也增加,代谢异常出现代代相传。虽然儿童代谢综合征的发生机制目前仍存在争议,但妊娠期糖尿病母亲高胰岛素、高血糖环境导致代谢及免疫紊乱,胎儿在宫内不良环境下也发生异常代谢变化,增加成人期代谢综合征的风险已有足够的证据。降低妊娠期糖尿病的发生率,加强孕母的健康教育,调整其生活方式及关注儿童期健康管理,可以降低妊娠期糖尿病母亲子代的远期疾病负担,减少代谢综合征的传递。

关键词: 妊娠期糖尿病, 大于胎龄儿, 肥胖, 代谢综合征

Abstract: Gestational diabetes mellitus has adverse impact on pregnant women and their offspring and increase the risk of metabolic syndrome for the posterity.Meanwhile,the incidence rate of macrosomia or large for gestational age infant will be increased and also the obesity rate of the children.However,the incidence of metabolic syndrome directly caused by gestational diabetes mellitus is still in controversy.Reports have point out that metabolic syndrome have some relations with hyperinsulinism,hyperglycemia and maternal metabolic and immunologic disturbance during pregnancy which can change the metabonomice of the fetus,which may increase the risk of metabolic syndrome.Hence,decreasing and controlling gestational diabetes mellitus,improving maternal realization for health herself and her offspring,adjusting her life styles and behaviors and managing their child after delivery may improve mother and child health and decrease the long term disease burden both for gestational diabetes mellitus and their children's,reduce the transmission of metabolic syndrome.

Key words: gestational diabetes mellitus, large for gestational age infant, obesity, metabolic syndrome

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