关键词: 血清铁, 总铁结合力, 转铁蛋白, 铁蛋白, 缺铁性贫血, 儿童

Abstract: Objective To investigate the changes and significance of serum iron (SI),total iron binding capacity (TIBC),transferrin (Tf) and ferritin (SF) in children with iron deficiency anemia (IDA) and to provide evidence for clinical treatment. Methods From January 2014 to February 2016,101 cases of anemia children were selected in Maternal and Child Health Hospital of Hainan Province,including 67 cases of IDA (IDA group),anemia of chronic disease (ACD) in 34 cases (ACD group),At the same time,100 healthy children were selected as control group.Serum levels of SI,TIBC,Tf and SF of each group were measured. Results Levels of SI and SF were (4.70±1.30) mol/L and (59.43±18.84) g/L in IDA group,significantly lower than those in control group and ACD group (P<0.05);Level of TIBC was (74.60±6.52) mol/L in IDA group,significantly higher than that in control group and ACD group (P<0.05);Level of Tf were (3.30±0.52) g/L and (3.35±0.60) g/L in IDA group and ACD group,significantly higher than that in control group (P<0.05);The areas of ROC curve of SI,TIBC and SF in the diagnosis of IDA were 0.837,0.822 and 0.755(P<0.05),Tf area under the ROC curve was 0.515(P>0.05); SI,TIBC and SF cut-off values were 6.99 mol/L,61.90 mol/L and 71.92 g/L,and the sensitivity were 73.50%,97.00% and 73.50%,the specificity were 94%,64.70% and 70.10% respectively. Conclusion SI,TIBC and SF are of certain value in the diagnosis of children iron deficiency anemia,and can be used as differential diagnosis index between iron deficiency anemia and anemia of chronic disease.

Key words: serum iron, total iron binding capacity, transferrin, ferritin, iron deficiency anemia, children