关键词: 维生素D, 重症肺炎, 儿童, 血清25-(OH)D水平

Abstract: Objective To study the difference of serum 25-hydroxyvitamin D(25-(OH)D) level between children with severe pneumonia and healthy children,and to provide a theoretical basis for vitamin D supplementation to reduce the incidence of severe pneumonia.Methods Using case-control study,sixty-four children with severe pneumonia treated in Department of Pediatrics of the Affiliated Hospital of Yan'an University from January 2014 to December 2016 were selected as severe pneumonia group,and sixty healthy children with the same age in the same period of physical examination were selected as healthy control group.The levels of serum 25-(OH)D in the two groups detected by chemiluminescence method were analyzed.Results Serum 25-(OH)D levels in children with severe pneumonia were significantly lower than those in healthy controls (P<0.01);The constituent ratios of normal (9%) and deficiency (19%) of vitamin D in severe pneumonia group were significantly lower than those in healthy control group (33%,42%,all P<0.05).While the ratios of deficiency (38%) and sever deficiency (30%) in severe pneumoria group were significantly higher than those of the healthy control group (15%,10%,all P<0.01).Conclusions Vitamin D deficiency is prevalent in children.Serum 25 (OH) D level in children with severe pneumonia is significantly lower than that in healthy children.Vitamin D supplementation in reducing the morbidity of severe pneumonia in infants and young children is still to be further studied.

Key words: vitamin D, severe pneumonia, children, serum 25 (OH) D levels