关键词: 妊娠期胆汁淤积综合征, 妊娠结局, 新生儿疾病

Abstract: Objective To investigate the effect of intrahepatic cholestasis of pregnancy(ICP) on pregnancy outcomes and neonates. Methods A total of 173 pregnant women who were diagnosed with ICP and delivered in gynecology department of Guizhou Provincial People's Hospital were classified as ICP group,and 180 healthy pregnant women were classified as control group from May 2013 to April 2017.Related indexs including maternal age,gravidity,parity,delivery mode,pregnancy outcomes and the neonatal laboratory indexes and diseases were collected and compared between the two groups. Results There was no significant difference on maternal age and times of pregnancy between the two groups,but the times of gravidity and the proportions of cesarean section in ICP group were significantly higher than those in control group (P<0.05);The proportions of low birth weight infants,meconium stained amniotic fluid,and asphyxia in ICP group were significantly higher than those in control group (P<0.05);The levels of TC,ALP and TBA in ICP group were significantly higher than those in control group (P<0.05). Conclusion ICP can cause neonatal birth and postpartum abnormalities,such as low birth weight infants,meconium stained amniotic fluid,asphyxia,and neonatal ALP,TBA abnormalities.

Key words: intrahepatic cholestasis of pregnancy, pregnancy outcome, neonatal diseases