关键词: 哮喘, creola小体, 毛细支气管炎, 婴幼儿

Abstract: Objective To investigate the relationship of creola body in sputum with the disease severity,hospital stay and allergy history in chidren with bronchiolitis,and to discuss the early predictive value of creola bodies for asthma. Methods A total of 114 infants with first wheezing were enrolled in this study from September 2012 to March 2015.The relationship between creola bodies score and the following conditions was evaluated,such as the severity of patient's condition,length of hospital stay and the number of children who developed asthma or unremitting wheezing. Results Creola body score was correlated with the severity of disease,hospital stays and allergy history (all P<0.05).Also,creola body score had a strong predictive value for unremitting asthma.With the increase of creola body score,the sensitivity,specficity and positive predictive value also increased.The sensitivity,specificity and positive predictive value of creola boby score 5 were 38.88%,96.77%,and 77.77% respectively. Conclusions The creola body has strong correlation with disease severity,hospital stays and allergy history.Creola body also has a strong predictive value for unremitting wheezing and asthma.

Key words: asthma, creola body, bronchiolitis, infants