环境因素与孤独症谱系障碍关系的研究进展

doi:10.11852/zgetbjzz2018-26-04-12

中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (4): 392-395.DOI: 10.11852/zgetbjzz2018-26-04-12

环境因素与孤独症谱系障碍关系的研究进展

魏亚敏, 姜志梅, 郭岚敏, 王亚男

佳木斯大学附属第三医院,佳木斯大学康复医学院,黑龙江佳木斯 154002;

收稿日期:2017-09-30 发布日期:2018-04-10 出版日期:2018-04-10
通讯作者: 姜志梅:E-mail:mynard93@163.com
作者简介:魏亚敏(1990-),女,河南人,硕士学位,主要研究方向为儿童脑发育与行为障碍。

Research progress on the relationship between environmental factors and autism spectrum disorder

WEI Ya-min, JIANG Zhi-mei, GUO Lan-min, WANG Ya-nan

The Third Affiliated Hospital of Jiamusi University,the School of Rehabilitation Medical of Jiamusi University,Jiamusi,Heilongjiang 154002,China

Received:2017-09-30 Online:2018-04-10 Published:2018-04-10
Contact: JIANG Zhi-mei,E-mail:mynard93@163.com

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)是一组起病于儿童早期的神经发育障碍性疾病,是遗传学、免疫学、表观遗传学和环境等多因素共同作用的结果。近年来,环境因素成为国内外ASD发病机制研究的热点,故本文对与ASD发病相关的环境因素进行综述。

关键词: 孤独症谱系障碍, 环境因素, 炎症反应

Abstract: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that cause onset in early childhood and is the result of a combination of genetics,immunology,epigenetics and the environment.In recent years,environmental factors have become research highlights in the study of pathogenesis of ASD at home and abroad.Therefore,this review summarizes the environmental factors related to the pathogenesis of ASD.

Key words: autism spectrum disorder, environmental factors, inflammatory reaction

中图分类号:

R179

魏亚敏, 姜志梅, 郭岚敏, 王亚男. 环境因素与孤独症谱系障碍关系的研究进展[J]. 中国儿童保健杂志, 2018, 26(4): 392-395.

WEI Ya-min, JIANG Zhi-mei, GUO Lan-min, WANG Ya-nan. Research progress on the relationship between environmental factors and autism spectrum disorder[J]. journal1, 2018, 26(4): 392-395.

参考文献

[1] Lee PF,Thomas RE,Lee PA.Approach to autism spectrum disorder:Using the new DSM-V diagnostic criteria and the Can MEDS-FM framework[J].Can Fam Physician,2015,61(5):421-424.
[2] Hallmayer J,Cleveland S,Torres A,et al.Genetic heritability and shared environmental factors among twin pairs with autism[J].Arch Gen Psychiatry,2011,68(11):1095-1102.
[3] Sasanfar R,Haddad SA,Tolouei A,et al.Paternal age increases the risk for autism in an Iranian population sample[J].Mol Autism,2010,1(1):222-226.
[4] Idring S,Magnusson C,Lundberg M,et al.Parental age and the risk of autism spectrum disorders:findings from a Swedish population-based cohort[J].Int J Epidemiol,2014,43(1):107-115.
[5] Kong A,Frigge ML,Masson G,et al.Rate of de novo mutations and the importance of father's age to disease risk[J].Nature,2012,488(7412):471-475.
[6] Wang Y,Tang S,Xu S,et al.Maternal body mass index and risk of autism spectrum disorders in offspring:a meta-analysis[J].Sci Rep,2016,6(34):248-252.
[7] Surén P,Gunnes N,Roth C,et al.Parental obesity and risk of autism spectrum disorder[J].Pediatrics,2014,133(5):1128-1138.
[8] Modabbernia A,Velthorst E,Reichenberg A,et al.Environmental risk factors for autism:an evidence-based review of systematic reviews and meta-analyses[J].Mol Autism,2017,8(13):231-237.
[9] Cheslack-Postava K,Suominen A,Jokiranta E,et al.Increased risk of autism spectrum disorders at short and long interpregnancy intervals in Finland[J].J Am Acad Child Adolesc Psychiatry,2014,53(10):1074-1081.
[10] Polo-Kantola P,Lampi KM,Hinkka-Yli-Salom ki S,et al.Obsteteic risk factors and autism spectrum disorders in Finland[J].J Pediatr,2014,164(2):358-365.
[11] Desbonnet L,Clarke G,Shanahan F,et al.Microbiota is essential for social development in the mouse[J].Molecular Psychiatry,2014,19(2):146-148.
[12] 韩钰.孕期环境危险因素暴露、机体转硫代谢异常及免疫功能失调与孤独症谱系障碍关系的研究[D].天津:天津医科大学,2016.
[13] Xiang AH,Wang X,Martinez MP,et al.Association of maternal diabetes with autism in offspring[J].JAMA,2015,313(14):1425-1434.
[14] Atladottir HO,Thorsen P,Ostergaard L,et al.Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders[J].J Autism Dev Disord,2010,40(12):1423-1430.
[15] Zerbo O,Qian Y,Yoshida C,et al.Maternal infection during pregnancy and autism spectrum disorders[J].JAMA Pediatr,2017,171(1):163-169.
[16] Filiano AJ,Xu Y,Tustison NJ,et al.Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour[J].Nature,2016,535(7612):425-429.
[17] Kalkbrenner AE,Windham GC,Serre ML,et al.Particulate matter exposure,prenatal and postnatal windows of susceptibility,and autism spectrum disorders[J].Epidemiology,2015,26(1):30-42.
[18] EI-Ansary A,Bjorklund G,Tinkov AA,et al.Relationship between selenium,lead,and mercury in red blood cells of Saudi autistic children[J].Metab Brain Dis,2017,32(4):1073-1080.
[19] Shelton JF,Geraghty EM,Tancredi DJ,et al.Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides:the CHARGE study[J].Environ Health Perspect,2014,122(10):1103-1109.
[20] Lyall K,Croen LA,Sj din A,et al.Polychlorinated biphenyl and organochlorine pesticide concentrations in maternal mid-pregnancy serum samples:association with autism spectrum disorder and intellectual disability[J].Environ Health Perspect,2017,125(3):474-480.
[21] 刘丹.儿童孤独症谱系障碍的环境危险因素研究[D].杭州:浙江大学,2016.
[22] Bauer AZ,Kriebel D.Prenatal and perinatal analgesic exposure and autism:an ecological link[J].Environ Health,2013,12(3):121-127.
[23] Gidaya NB,Lee BK,Burstyn I,et al.In uteroexposure to beta-2-adrenergic receptor agonist drugs and risk for autism spectrum disorders[J].Pediatrics,2016,137(2):1316-1321.
[24] 陈运华,勾云,周波,等.孤独症大鼠前额叶皮质突触相关蛋白的表达[J].中国儿童保健杂志,2017,25(5):470-473.
[25] Surén P,Roth C,Bresnahan M,et al.Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children[J].JAMA,2013,309(6):570-577.
[26] Castro K,Klein Lda S,Baronio D,et al.Folic acid and autism:what do we know[J].Nutr Neurosci,2016,19(7):310-317.
[27] Cartier E,Hamilton PJ,Belovich AN,et al.Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (HDAT R51W) in dopamine neurotransmission and behaviors[J].E Bio Medicine,2015,2(2):135-146.
[28] Eyles DW,Burne TH,McGrath JJ.Vitamin D,effects on brain development,adult brain function and the links between low levels of vitamin D and neuropsychiatric disease[J].Front Neuroendocrinol,2012,34(1):47-64.
[29] 段小燕.维生素D治疗儿童孤独症谱系障碍的初步研究[D].长春:吉林大学,2015.
[30] Durkin MS,Maenner MJ,Meaney FJ,et al.Socioeconomic inequality in the prevalence of autism spectrum disorder:evidence from a U.S.cross-sectional study[J].PLoS One,2010,5(7):115-119.
[31] Kinney DK,Miller AM,Crowley DJ,et al.Autism prevalence following prenatal exposure to hurricanes and tropical storms in Louisiana[J].J Autism and Dev Disord,2008,38(3):481-488.
[32] Sjaarda CP,Hecht P,McNaughton AM,et al.Interplay between maternal Slc6a4 mutation and prenatal stress:a possible mechanism for autistic behavior development[J].Sci Rep,2017,7(4):873-882.

环境因素与孤独症谱系障碍关系的研究进展

Research progress on the relationship between environmental factors and autism spectrum disorder

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