关键词: 肾上腺皮质激素, 皮质醇, 影响因素, 新生儿

Abstract: Objective To investigate the levels of adrenocorticotrophic hormone(ACTH) and cortisol(COR) in neonates,and to analyze the influencing factors,so as to provide evidence for the health care of neonates. Methods A total of 88 neonates born in the Obstetrical Department of Air Force Medical Center were enrolled in this study from October 2018 to February 2019. The levels of ACTH and COR in umbilical cord blood in 88 neonates were tested. And categorical regression method was used to analyze the effects of parturition mode,gestational age,gender,birth weight and maternal health during pregnancy on the levels of ACTH and COR in umbilical cord blood. Results The levels of ACTH and COR in 88 neonates were (172.11±93.93) pg/ml and (310.05±125.33) ng/ml,respectively. Single factor analysis showed that there were statistically significant differences on COR level of umbilical cord blood among neonates with different parturition modes and gestational age(P<0.01),while it was not significant on COR level among children with different gender,birth weight and maternal health during pregnancy(P＞0.05). Moreover,these variables had no significant influence on ACTH level(P＞0.05). The optimal scale regression analysis showed that parturition mode(β=-0.522),gender(β=-0.221),gestational age(β=0.284) and body weight(β=-0.260) had significant effects on the level of cord blood COR in neonates(P<0.05). Conclusion Parturition mode and gestational age are the main influencing factors of COR level in umbilical cord blood in healthy full-term newborns,while the gestational age,gender,birth weight and maternal pregnancy status involved in this study do not affect the level of ACTH.

Key words: adrenocortical hormone, cortisol, influencing factors, neonates