中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (11): 1219-1222.DOI: 10.11852/zgetbjzz2019-1662

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远隔缺血后处理对新生儿缺氧缺血性脑病的神经保护作用

宋琳, 郭津, 宋福祥, 张朋   

  1. 佳木斯大学康复医学院,黑龙江 佳木斯 154002
  • 收稿日期:2019-11-03 修回日期:2020-01-02 出版日期:2020-11-10 发布日期:2020-11-10
  • 通讯作者: 郭津,E-mail:guojin8002@163.com
  • 作者简介::宋琳(1992-),女,黑龙江人,硕士在读,主要研究方向为小儿脑瘫的综合康复。
  • 基金资助:
    国家自然科学基金(81300122);黑龙江省自然科学基金(QC2016130);佳木斯大学优秀学科团队(JDXKTD-2019006)

Neuroprotective effect of remote ischemic post-conditioning on neonatal hypoxic-ischemic encephalopathy

SONG Lin, GUO Jin, SONG Fu-xiang, ZHANG Peng   

  1. Rehabilitation Medicine of Jiamusi University,Jiamusi,Heilongjiang 154002,China
  • Received:2019-11-03 Revised:2020-01-02 Online:2020-11-10 Published:2020-11-10
  • Contact: GUO Jin,E-mail:guojin8002@163.com

摘要: 新生儿缺氧缺血性脑病是世界各国新生儿死亡和残疾的主要原因之一,主要由于围生期供应脑部的血流量减少或完全阻断所致,幸存新生儿大多存在运动障碍和认知障碍。远隔缺血性后处理作为目前治疗缺氧缺血性脑病的新兴疗法,具有易操作、廉价、安全等优点。并且能够通过减少梗死面积,减少脑水肿,改善神经细胞以及调节各种细胞通路减轻缺氧缺血性脑病神经损伤。本文通过远隔缺血后处理对于神经细胞的形态、信号转导通路以及预后的影响几方面简单阐述了远隔缺血后处理对新生儿缺氧缺血性脑病可达到脑保护的作用。

关键词: 缺氧缺血性脑病, 脑损伤, 远隔缺血, 新生儿

Abstract: Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the main causes of neonatal death and disability from all over the world,mainly due to the decrease or complete block of cerebral blood flow during perinatal period.And most newborn survivors have movement disorder and cognitive impairment.As a new treatment for HIE,remote ischemic post-conditioning (RIPostC) has many advantages,such as easy operation,low cost and safe.In addition,it can reduce the infarct area and brain edema,improve nerve cells and regulate various cell pathways to alleviate the nerve injury of HIE.In this paper,the effect of remote ischemic post-conditioning on the morphological signal transduction pathway and prognosis of nerve cells is briefly discussed.

Key words: hypoxic-ischemic encephalopathy, brain injury, remote ischemic post-conditioning, neonate

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