中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (1): 60-62.DOI: 10.11852/zgetbjzz2019-1784

• 综述 • 上一篇    下一篇

胆道闭锁患儿微量营养素缺乏及防治研究进展

鲜若凌, 胡燕, 李英存   

  1. 重庆医科大学附属儿童医院儿童保健科、肝胆外科;儿童发育疾病研究教育部重点实验室;国家儿童健康与疾病医学研究中心;儿童发育重大疾病国家国际科技合作基地;儿童营养与健康重庆市重点实验室,重庆 400014
  • 收稿日期:2019-11-23 修回日期:2020-02-15 出版日期:2021-01-10 发布日期:2021-01-10
  • 通讯作者: 李英存,E-maillyc@163.com
  • 作者简介:鲜若凌(1995-),女,重庆人,住院医师,在读研究生,主要研究方向为儿童保健方向。
  • 基金资助:
    重庆市科委社会民生面上项目(cstc2018jscx-msyb0058)

Progress on the treatment and prevention of micronutrient deficiency in children with biliary atresia

XIAN Ruo-ling, HU Yan, LI Ying-cun   

  1. Department of Child Health Care and Hepto-biliary Surgery;Ministry of Education Key Laboratory of Child Development and Disorders;National Clinical Research Center for Child Health and Disorders;China International Science and Technology Cooperation Base of Child Development and Critical Disorders;Chongqing Key Laboratory of Child Health and Nutrition;Children's Hospital of Chongqing Medical University,Chongqing 400014,China
  • Received:2019-11-23 Revised:2020-02-15 Online:2021-01-10 Published:2021-01-10
  • Contact: LI Ying-cun,E-mail:lyc@163.com

摘要: 胆道闭锁是新生儿胆汁淤积的常见原因,也是儿童肝移植最主要的原发病,若不及时治疗,预后不良。而因胆道梗阻,导致消化吸收及代谢等多方面障碍,此类患儿常伴有营养不良,其中微量营养素,特别是脂溶性维生素的缺乏不仅会导致病情加重,还可能并发其他临床症状。本文通过查阅相关文献,就胆道闭锁患儿的微量营养素缺乏现状、相关机制及支持方案等进行综述,为临床改善患儿营养状况及预后提供参考和帮助。

关键词: 胆道闭锁, 营养不良, 微量营养素

Abstract: Biliary atresia (BA) is a common cause for cholestasis in neonates and is also the main disease for liver transplantation in children.Poor prognosis may occur for delayed treatment.Patients may accompany with malnutrition due to negative effect on digestion,absorption,metabolism caused by biliary obstruction.The lack of micronutrients,especially fat-soluble vitamins,may not only lead to the aggravation of the disease,but also cause other clinical symptoms.Therefore,this paper reviews the status,mechanisms,treatment and prevention of micronutrient deficiency in children with BA,thus to provide support for improvement of nutritional status and prognosis of these children.

Key words: biliary atresia, malnutrition, micronutrient

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