围孕期增补叶酸对子代哮喘及过敏性疾病的影响

doi:10.11852/zgetbjzz2020-0512

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (8): 861-864.DOI: 10.11852/zgetbjzz2020-0512

围孕期增补叶酸对子代哮喘及过敏性疾病的影响

张耀云¹, 刘菊芬²

1.北京大学公共卫生学院,北京 100191;
2.北京大学生育健康研究所/国家卫生健康委员会生育健康重点实验室,北京大学公共卫生学院流行病与卫生统计学系

收稿日期:2020-03-21 修回日期:2020-11-12 发布日期:2021-08-24 出版日期:2021-08-10
通讯作者: 刘菊芬,E-mail:liujufen@bjmu.edu.cn
作者简介:张耀云(2000-),女,山西人,本科生在读,主要研究方向为围生期保健。
基金资助:
国家自然科学基金(81202265);2020年度北京大学公共卫生与预防医学学科建设项目(BMU2020XY010)

Effect of folic acid supplementation during pregnancy on childhood asthma and allergic diseases

ZHANG Yao-yun^*, LIU Ju-fen

^*School of Public Health, Peking University, Beijing 100191, China

Received:2020-03-21 Revised:2020-11-12 Online:2021-08-10 Published:2021-08-24
Contact: LIU Ju-fen, E-mail: liujufen@bjmu.edu.cn

摘要/Abstract

摘要： 哮喘是一种复杂的、异质性的慢性炎症疾病,致病机制尚不清楚,关于儿童哮喘及过敏性疾病的危险因素一直是研究热点。叶酸作为人体的必需营养素之一,在围孕期适量增补叶酸能够显著降低胎儿神经管缺陷等先天性异常的发生风险,同时,一些研究也发现增补叶酸会影响子代哮喘及过敏性疾病发生的风险,但是尚未得出一致结论。目前的研究仍存在一些问题,同时,叶酸增补的远期健康效应也值得随访追踪。

关键词: 叶酸, 哮喘, 妊娠结局, 过敏性疾病

Abstract: Asthma is a complex and heterogeneous chronic inflammatory disease with unclear pathogenesis.The risk factors of childhood asthma and allergic diseases have been the focus of research. As an essential nutrient, folic acid's supplementation during pregnancy can significantly reduce the risk of neural tube defects and other congenital abnormalities.At the same time, some studies have found that folic acid supplementation can affect the risk of asthma and allergic diseases in offspring.There are still some problems with the current researches.Meanwhile, further follow-up studies are warranted to explore the long-term health effects of folic acid supplementation.

Key words: folic acid, asthma, pregnancy outcome, allergic disease

中图分类号:

R715.3

张耀云, 刘菊芬. 围孕期增补叶酸对子代哮喘及过敏性疾病的影响[J]. 中国儿童保健杂志, 2021, 29(8): 861-864.

ZHANG Yao-yun, LIU Ju-fen. Effect of folic acid supplementation during pregnancy on childhood asthma and allergic diseases[J]. Chinese Journal of Child Health Care, 2021, 29(8): 861-864.

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围孕期增补叶酸对子代哮喘及过敏性疾病的影响

Effect of folic acid supplementation during pregnancy on childhood asthma and allergic diseases

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