中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (8): 865-868.DOI: 10.11852/zgetbjzz2020-0802

• 综述 • 上一篇    下一篇

注意缺陷多动障碍与肠道菌群的关系研究进展

王亚平, 邓岚柳, 刘芮卓 综述, 陈立 审校   

  1. 重庆医科大学附属儿童医院儿童青少年生长发育与心理健康中心/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿童发育重大疾病国家国际科技合作基地/认知发育与学习记忆障碍转化医学重庆市重点实验室/儿童营养与健康重庆市重点实验室,重庆 400014
  • 收稿日期:2020-05-01 修回日期:2020-07-02 出版日期:2021-08-10 发布日期:2021-08-24
  • 通讯作者: 陈立,E-mail:chenli@cqmu.edu.cn,chenli2012@126.com
  • 作者简介:王亚平(1993-),女,重庆人,住院医师,在读硕士研究生,主要研究方向为儿童发育障碍性疾病。
  • 基金资助:
    重庆市技术创新与应用示范项目社会民生类重点研发项目(cstc2018jscx-mszdX0023)。

Research progress on the relationship between attention-deficit/hyperactivity disorder and gut microbiota

WANG Ya-ping, DENG Lan-liu, LIU Rui-zhuo, CHEN Li   

  1. Department of Child Health Care, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing Key Laboratory of Child Nutrition and Health, Chongqing 400014,China
  • Received:2020-05-01 Revised:2020-07-02 Online:2021-08-10 Published:2021-08-24
  • Contact: CHEN Li, E-mail: chenli@cqmu.edu.cn, chenli2012@126.com

摘要: 注意缺陷多动障碍(ADHD)是儿童最常见的神经发育障碍之一,表现为与发育程度不相符的注意力不集中、多动、冲动,并伴有社交、学业等方面的功能损害。目前ADHD的病因尚不清楚,普遍认为ADHD是由遗传、环境及其交互作用共同引起的一种行为疾病,可能与额叶纹状体脑功能障碍和单胺神经递质系统功能受损有关。不同的肠道菌群可产生不同的神经递质,通过微生物-肠-脑轴的双向交流参与对中枢神经系统的调控。因此,了解肠道菌群、微生物-肠-脑轴和ADHD之间的相互作用可能为ADHD的早期干预和治疗开辟新的途径。

关键词: 注意缺陷多动障碍, 肠道菌群, 微生物-肠-脑轴, 肠道菌群多样性

Abstract: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children, which is characterized by inattention, hyperactivity and impulsivity that are not consistent with the developmental level, accompanied by functional impairment in social and academic performance.At present, the etiology of ADHD is not yet clear.It is generally believed that ADHD is a kind of behavioral disease caused by genetics, environment and their interaction, which may be related to dysfunction of the fronto-striatal brain and monoamine neurotransmitter system.Different gut microbiota can produce different neurotransmitters, participating in the regulation of the central nervous system through bidirectional communication of microbiota-gut-brain axis.Therefore, it will open up a new way for early intervention and treatment of ADHD.

Key words: attention-deficit/hyperactivity disorder, gut microbiota, microbiota-gut-brain axis, gut microbial diversity

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