中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (3): 318-322.DOI: 10.11852/zgetbjzz2020-1518

• 临床研究 • 上一篇    下一篇

早发型重度子痫前期出生早产儿临床相关不良结局的研究

钟美珍, 李小忠, 王礼周, 陈先睿   

  1. 厦门大学附属第一医院儿科,厦门市儿科重点实验室,厦门大学医学院儿童医学研究所,福建 厦门 361003
  • 收稿日期:2020-08-12 修回日期:2020-10-23 出版日期:2021-03-10 发布日期:2021-03-10
  • 通讯作者: 钟美珍,E-mail:zmzxiamen@163.com
  • 作者简介:钟美珍(1969-),女,福建人,主任医师,医学硕士,主要研究方向为新生儿专业。

Study on the clinicalpoor outcomes of premature infants born by early-onset severe-preeclampsia

ZHONG Mei-zhen, LI Xiao-zhong, WANG Li-zhou, CHEN xian-rui   

  1. Department of Pediatrics, the First Affiliated Hospital of Xiamen University; Pediatric Key Laboratory of Xiamen; Institute of Pediatrics, School of Medicine, Xiamen University, Xiamen, Fujian 361003, China
  • Received:2020-08-12 Revised:2020-10-23 Online:2021-03-10 Published:2021-03-10

摘要: 目的 探讨早发型重度子痫前期(ES-PE)对早产儿临床疾病的影响。 方法 前瞻性地选择2016年1月-2017年12月在厦门大学附属第一医院分娩的孕周≤34周的活产早产儿为研究对象,按暴露因素孕母有无重度子痫前期(S-PE)分为研究组与对照组,观察早产儿的临床结局,收集相关资料进行临床分析。 结果 研究期间共出生≤34周的活产早产儿814例,研究组早产儿107例,符合随访条件101例,对照组早产儿707例,符合随访条件640例。研究组早产儿中剖宫产、新生儿出生窒息、中性粒细胞减少症、血小板减少症、院内感染、喂养不耐受、新生儿呼吸窘迫综合征(NRDS)、支气管肺发育不良(BPD)等发生率明显增加,差异有统计学意义(χ2=68.722、13.073、15.759、14.910、5.221、4.515、8.117、4.192, P<0.05)。研究组平均出生体重低于对照组(t=-2.120,P<0.05),平均住院时间明显长于对照组(t=2.862,P<0.05),两组新生儿坏死性小肠结肠炎(NEC)、Ⅲ~Ⅳ度早产儿脑室内出血(IVH)、早产儿视网膜病变(ROP)、新生儿死亡率差异无统计学意义(P>0.05)。结论 早发型重度子痫影响早产儿出生方式和出生体重,增加早产儿并发症的发生率,使其住院时间延长,但未增加死亡率。

关键词: 结局, 婴儿, 早产, 重度子痫, 早发型

Abstract: Objective To discuss the impact of early-onset severe-preeclampsia(ES-PE) on the clinical outcomes of premature infants. Methods All the live-birth preterm infants with gestational age ≤34 weeks, delivered by women with early-onset severe-preeclampsia in the First Affiliated Hospital of Xiamen University from January 2016 to December 2017, were recruited prospectively in this study.Premature infants were divided into study group and control group according to whether their mother had ES-PE during pregnancy or not.The clinical outcomes of the preterm infants were observed, and the related clinical data were collected for analysis. Results Totally 814 live-birth preterm infants with gestational age ≤34 weeks were delivered during this study period, with 107 in study group and 707 in control group.Finally infants who met the follow-up criteria in the study group and control group were 101 and 640 cases, respectively.Compared with control group, the incidence rates of cesarean section, neonatal birth asphyxia, neutropenia, thrombocytopenia, nosocomial infections, feeding intolerance, neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD) increased significantly in study group(χ2=68.722, 13.073, 15.759, 14.910, 5.221, 4.515, 8.117, 4.192, P<0.05).The average birth weight of the study group was less than that of control group (t=-2.120, P<0.05), while the average hospitalization day of the study group was longer than that of the control group (t=2.862, P<0.05) between the two groups(P>0.05). Conclusion ES-PE affects the birth way and birth weight of preterm infants, increases adverse events rate, hospitalization day in preterm infants, but has no impact on neonatal mortality.

Key words: outcome, infant, premature, severe preeclampsia, early-onset

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