中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (3): 276-280.DOI: 10.11852/zgetbjzz2021-0078

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微小RNA与儿童神经精神障碍之间关系的研究进展

张红梅1, 贾美香2, 李素水3, 薛曼3, 孙志刚3   

  1. 1.石家庄市第八医院心理危机干预中心,河北 石家庄 050000;
    2.北京大学第六医院;
    3.石家庄市第八医院
  • 收稿日期:2021-01-18 修回日期:2021-04-29 出版日期:2022-03-10 发布日期:2022-03-18
  • 通讯作者: 李素水,E-mail:sbylss@163.com
  • 作者简介:张红梅(1975-),女,河北人,副主任医师,本科学历,主要研究方向为精神分裂症患者心理康复治疗。
  • 基金资助:
    河北省科技计划项目(152777223)

Research progress on the relationship between microRNA and neuropsychiatric disorders in children

ZHANG Hong-mei*, JIA Mei-xiang, LI Su-shui, XUE Man, SUN Zhi-gang   

  1. *Psychological Crisis Intervention Center, the Eighth Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050000,China
  • Received:2021-01-18 Revised:2021-04-29 Online:2022-03-10 Published:2022-03-18
  • Contact: LI Su-shui,E-mail:sbylss@163.com

摘要: 微小RNA是一组短的内源性非编码RNA分子,具有调控基因表达作用,对中枢神经系统神经元增殖、分化、突触形成、突触可塑性和细胞凋亡有重要作用。大量研究证实不同脑区的微小RNA表达模式改变可能参与了孤独症谱系障碍等儿童神经精神障碍的发生和发展,微小RNA有望成为早期诊断的生物学标记物和研制新药的靶目标。

关键词: 微小RNA, 儿童神经精神障碍, 生物学标记物, 神经发育障碍

Abstract: MicroRNA is a group of short endogenous non-coding RNA molecules that regulate gene expression and play an important role in the proliferation, differentiation, synaptic formation, synaptic plasticity and apoptosis of neurons in the central nervous system.A large number of studies have confirmed that changes in the expression pattern of microRNA in different brain regions may be involved in the occurrence and development of children's neuropsychiatric disorders such as autism spectrum disorders.MicroRNA is expected to become a biomarker for early diagnosis and a target for the development of new drugs.

Key words: microRNA, child neuropsychiatric disorder, biomarker, neurodevelopmental disorder

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