中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (3): 268-271.DOI: 10.11852/zgetbjzz2021-1008

• 科研论著 • 上一篇    下一篇

学龄前正常儿童应用事件相关电位N400的探索性研究

朱一可1, 尹悦1, 刘思奇1, 张樊1, 王小月1, 任永颖1, 孙静1, 王昕1, 王琳2, 杨健1   

  1. 1.首都儿科研究所附属儿童医院神经内科,北京 100020;
    2.首都儿科研究所附属儿童医院保健科
  • 收稿日期:2021-07-01 修回日期:2021-09-01 出版日期:2022-03-10 发布日期:2022-03-18
  • 通讯作者: 杨健,E-mail:yangjian1306@sina.com
  • 作者简介:朱一可(1995-),女,湖北人,硕士研究生在读,主要从事神经电生理及神经发育障碍疾病的研究。
  • 基金资助:
    国家重点研发计划(2016YFC1306204);首都卫生发展科研专项项目(首发2020-1-4111)

Exploration of the N400 event-related potential in normal preschool children

ZHU Yi-ke*, YIN Yue, LIU Si-qi, ZHANG Fan, WANG Xiao-yue, REN Yong-ying, SUN Jing, WANG Xin, WANG Lin, YANG Jian   

  1. *Department of Neurology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China
  • Received:2021-07-01 Revised:2021-09-01 Online:2022-03-10 Published:2022-03-18
  • Contact: YANG Jian, E-mail: yangjian1306@sina.com

摘要: 目的 了解学龄前正常儿童事件相关电位N400潜伏期、波幅特点和发展规律,为早期发现学龄前儿童语言认知功能障碍提供客观依据。方法 对2015年8月-2020年1月健康体检的220例3~5岁学龄前正常儿童进行事件相关电位检测,采用声影匹配任务刺激,记录头皮电极Fz、Cz和Pz点N400的潜伏期和波幅。其中对127例记录了F3、F4点N400的潜伏期和波幅。结果 学龄前正常儿童3~5岁组N400的潜伏期随年龄增加有逐渐缩短的趋势,但其差异无统计学意义(P >0.05);N400的波幅存在随着年龄增长逐渐降低的趋势,在Fz点和Cz点3岁~组和4岁~组 [ Fz点(-10.95±9.78) vs.(-6.40±6.53)μV, Cz点(-12.48±9.45) vs.(-7.71±7.80)μV] 、3岁~组和5岁~组[Fz点(-10.95±9.78) vs.(-7.01±7.47)μV,Cz点(-12.48±9.45) vs.(-7.62±7.90)μV]的差异有统计学意义(P < 0.05)。性别和左右侧对学龄前儿童N400潜伏期和波幅的影响不显著(P >0.05)。结论 学龄前儿童的N400波形清晰稳定,潜伏期和波幅随着年龄增长而变化。

关键词: 事件相关电位, N400, 学龄前儿童

Abstract: Objective To study the latency, waveform characteristics and development of the N400 component of event-related potential in normal preschool children, so as to provide Objective indicators for early detection of language cognitive impairment in preschool children. Methods A total of 220 normal preschool children aged 3 to 5 years who took physical examination from August 2015 to January 2020 performed sound and shadow matching tasks, and event-related potentials were tested, then the latency and amplitude of N400 in scalp electrodes FZ, CZ, and PZ were recorded.The latency and amplitude of N400 in F3 and F4 were recorded in 127 cases. Results The latency of N400 in 3- to 5-year-old children showed a decreasing trend gradually with increasing age, but the difference was not statistically significant (P>0.05).The amplitude of N400 showed a tendency to decrease gradually with age, and the differences was significant in FZ and CZ between 3-year-old children and 4-year-old children [Fz: (-10.95±9.78)μV vs.(-6.40±6.53)μV,Cz: (-12.48±9.45)μV vs.(-7.71±7.80)μV], between 3-year-old children and 5-year-old children [Fz:(-10.95±9.78)μV vs.(-7.01±7.47)μV, Cz: (-12.48±9.45)μV vs.(-7.62±7.90)μV] (P<0.05).Effects of gender and lateralization on N400 latency and amplitude in preschool children were not significant (P>0.05). Conclusion The waveform of N400 is clear and stable in preschool children, with latency and amplitude changing with age.

Key words: event-related potential, N400, preschool children

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