关键词: 内脏脂肪面积, 尿酸, 肥胖, 儿童

Abstract: Objective To explore the correlation between visceral fat area (VFA) and uric acid level in school-age children, so as to provide reference for preventing hyperuricemia (HUA) of children. Methods Data were from school-based cardiovascular and bone health promotion program (SCVBH), and 10 609 children and adolescents aged 8 to 18 years were finally included for analysis. The correlation between VFA and cardiovascular metabolic parameters was analyzed by Spearman correlation analysis. The body type was divided into four groups according to obesity diagnosed by body mass index (BMI) and VFA. The association between different obesity types and HUA was analyzed by multivariate Logistic regression, and the potential confounding factors such as age, blood pressure, blood glucose and blood lipids were adjusted. Results VFA increased gradually with growth and development of children, and the gender difference was significant. VFA was positively correlated with uric acid level in boys and girls (r=0.399, 0.375, P＜0.001). The prevalence of HUA increased successively among the non-overweight, overweight and obesity group divided by BMI (28.9%, 43.5% and 52.1% for boys, 6.0%, 15.9% and 32.4% for girls, respectively). The prevalence of HUA in the obesity group evaluated by VFA was significantly higher than that in the non-overweight group (57.5% vs. 33.7% for boys, 31.6 % vs. 7.7 % for girls, P <0.001). After adjusting the confounding factors such as age, blood pressure, blood glucose and blood lipid, the ORs and 95%CIs of risk for HUA were 2.70 (95%CI: 1.36 - 5.35) in boyswith simple abdominal obesity.and 4.74 (95%CI:3.77 - 5.95) in girls with mixed obesity. Conclusions VFA is closely related to uric acid levels in children. Body composition analysis in health examination can early detect obesity in children, which is also of great significance for prevention and control of HUA in children.

Key words: visceral fat area, uric acid, obesity, children