静息态功能磁共振成像在评估阻塞性睡眠呼吸暂停儿童情绪障碍中的应用

doi:10.11852/zgetbjzz2022-0030

中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (12): 1341-1344.DOI: 10.11852/zgetbjzz2022-0030

静息态功能磁共振成像在评估阻塞性睡眠呼吸暂停儿童情绪障碍中的应用

金玲凛, 陈洁

上海交通大学医学院附属上海儿童医学中心耳鼻咽喉口腔颌面外科,上海 200127

收稿日期:2022-01-06 修回日期:2022-04-07 发布日期:2022-11-30 出版日期:2022-12-10
通讯作者: 陈洁,E-mail: 13611715123@163.com
作者简介:金玲凛(1998-),女,浙江人,硕士研究生在读,主要研究方向为儿童睡眠片段化的脑损害。
基金资助:
国家自然科学基金资助项目(81900939)

Application of resting-state functional magnetic resonance imaging in evaluating emotional disorders among obstructive sleep apnea children

JIN Ling-lin, CHEN Jie

Department of Otolaryngology and Oral & Maxillofacial Surgery, Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Received:2022-01-06 Revised:2022-04-07 Online:2022-12-10 Published:2022-11-30
Contact: CHEN Jie,E-mail: 13611715123@163.com

摘要/Abstract

摘要： 阻塞性睡眠呼吸暂停(OSA)在儿童中较为常见,其特征性病理生理学改变为间歇性缺氧(IH)和睡眠片段化(SF)。OSA可能导致儿童情绪障碍,其神经生物学机制尚不明确。目前研究表明,炎症反应和氧化应激在OSA患儿情绪障碍中起到了重要作用。静息态功能磁共振成像(rs-fMRI)是检测OSA患者脑功能损伤的理想影像学工具。本文综述了OSA患儿脑功能损伤的神经生物学基础研究与rs-fMRI临床研究,旨在寻找目标脑区,探究损伤机制,为OSA患儿情绪障碍早期诊断和治疗提供新思路。

关键词: 阻塞性睡眠呼吸暂停, 儿童, 静息态功能磁共振成像, 情绪障碍, 神经生物学机制

Abstract: Obstructive sleep apnea (OSA) is common in children, which is characterized bypathophysiological alterations of intermittent hypoxia (IH)and sleep fragmentation(SF). OSA may result in emotional disorders in children, while its neurobiological mechanisms remain unknown. Recent studies have shown that inflammatory response and oxidative stress play important roles in emotional disorders of OSA children. Resting-state functional magnetic resonance imaging (rs-fMRI) is an ideal imaging tool for the detection of brain injuries in OSA children. This article reviews the neurobiological researches concerning cerebral injuries in OSA and relevant clinical trials on rs-fMRI, aiming to find the target brain areas and mechanisms which may provide a new outlook on the early diagnosis and treatment of emotional disorders in OSA children.

Key words: obstructive sleep apnea, children, resting-state functional magnetic resonance imaging, emotional disorder, neurobiological mechanism

中图分类号:

R445.2
R766

金玲凛, 陈洁. 静息态功能磁共振成像在评估阻塞性睡眠呼吸暂停儿童情绪障碍中的应用[J]. 中国儿童保健杂志, 2022, 30(12): 1341-1344.

JIN Ling-lin, CHEN Jie. Application of resting-state functional magnetic resonance imaging in evaluating emotional disorders among obstructive sleep apnea children[J]. Chinese Journal of Child Health Care, 2022, 30(12): 1341-1344.

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静息态功能磁共振成像在评估阻塞性睡眠呼吸暂停儿童情绪障碍中的应用

Application of resting-state functional magnetic resonance imaging in evaluating emotional disorders among obstructive sleep apnea children

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