中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (4): 349-351.DOI: 10.11852/zgetbjzz2022-0335

• 专家笔谈 •    下一篇

营养素信号通路作为孤独症谱系障碍生物标志的进展和思考

李廷玉   

  1. 重庆医科大学附属儿童医院/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿童营养与健康重庆市重点实验室,重庆 400014
  • 出版日期:2022-04-10 发布日期:2022-04-11
  • 作者简介:李廷玉(1956-),女,重庆人,教授,博士生导师,主要研究方向为儿童营养与行为发育。
  • 基金资助:
    国家自然科学基金面上项目(81771223);广东省科技项目(2018B030335001);广州市科技项目(202007030002)

Advances and reflections on nutrient signalling pathways as biomarkers of autism spectrum disorders

LI Ting-yu   

  1. Children's Hospital of Chongqing Medical University/ National Clinical Research Center for Child Health and Disorders/ Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400014, China
  • Online:2022-04-10 Published:2022-04-11

摘要: 孤独症谱系障碍(ASD)是常见的复杂神经发育障碍,营养是儿童生长发育的重要因素,其与ASD亚型的发生、发展及预后存在一定关联,随着研究的深入,发现单用血清营养素水平关联ASD的症状受到极大挑战。本文以叶酸、维生素A(VA)为例综述了将营养素信号通路作为ASD潜在生物标志物的新思路,望对进一步探寻ASD的发生、诊治起到抛砖引玉作用。

关键词: 孤独症谱系障碍, 营养素, 儿童营养, 遗传背景, 信号通路

Abstract: Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder. Nutrition plays an important role in the growth and development of children, and there is a certain relationship with the occurrence, development and prognosis of ASD subtypes. With the deepening of research, correlating ASD symptoms with serum nutrient levels has been extremely challenging. This manuscript takes folic acid and vitamin A (VA) as examples to review the new ideas of using nutrient signaling pathway as a potential biomarker of ASD, hoping to provide reference for further exploring the occurrence, diagnosis and treatment of ASD.

Key words: autism spectrum disorder, nutrients, child nutrition, genetic background, signalling pathways

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