学龄期肥胖儿童注意认知事件相关电位及行为学研究

doi:10.11852/zgetbjzz2022-0628

中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (12): 1371-1375.DOI: 10.11852/zgetbjzz2022-0628

学龄期肥胖儿童注意认知事件相关电位及行为学研究

倪曼曼¹, 王超群², 汪莹莹¹, 董选², 董毓¹, 殷志萍³, 沈惠娟¹

1.南通大学附属常州儿童医院儿童发育行为科,江苏常州 213000;
2.南通大学附属常州儿童医院儿童健康研究中心;
3.南通大学附属常州儿童医院儿科

收稿日期:2022-05-22 修回日期:2022-09-19 发布日期:2022-11-30 出版日期:2022-12-10
通讯作者: 沈惠娟,E-mail:942238277@qq.com
作者简介:倪曼曼(1987-),女,安徽人,主治医师,硕士学位,主要研究方向为儿童肥胖与认知。
基金资助:
江苏省妇幼健康科研项目(F202061);常州市应用基础研究计划(CJ20190029);常州市卫健委青年人才科技项目(QN201944)

Attention cognitive event-related potentials and behaviors of school-age obese children

NI Man-man^*, WANG Chao-qun, WANG Ying-ying, DONG Xuan, DONG Yu, YIN Zhi-ping, SHEN Hui-juan

^*Developmental Behavioral Department, Changzhou Children′s Hospital of Nantong University, Changzhou, Jiangsu 213000, China

Received:2022-05-22 Revised:2022-09-19 Online:2022-12-10 Published:2022-11-30
Contact: SHEN Hui-juan, E-mail:942238277@qq.com

摘要/Abstract

摘要： 目的采用提示性靶/非靶(Go/Nogo)任务模式,通过事件相关电位(ERP)和行为监测,探讨儿童肥胖与注意认知控制之间的关系,为肥胖儿童注意力问题的早发现早干预提供依据。方法 2019年8月—2021年8月从常州儿童医院肥胖门诊选取肥胖儿童38例,同期在常州某小学选取正常儿童41人,采用持续注意范式(CPT)进行脑电测试,记录并比较ERP及行为学数据。结果 1)行为层面,与正常组相比,肥胖组儿童正确击中数明显减少[37(35,39)个 vs. 39(38,40)个,Z=-3.459,P=0.001],反应时延长[(502.21±95.29)ms vs.(454.45±95.24)ms,t=2.210,P=0.030],反应时变异性高[147.74±50.15)ms vs.(105.89±44.87)ms,t=3.330,P=0.001),两组间虚报个数差异无统计学意义(P＞0.05)。2)认知层面,Go、Nogo条件下肥胖组与正常组N2波幅及潜伏期均差异不显著;肥胖组儿童的P3 Nogo/Go效应明显弱于正常组,肥胖儿童Nogo-P3波幅显著低于对照组[(16.47±8.46)μV vs.(21.58±7.91)μV,t=-2.771,P=0.007]。结论肥胖儿童存在持续注意认知障碍,表现在行为层面的击中数减少和反应变异时增加,肥胖儿童的冲突监测能力与正常儿童相当,但其主动抑制能力受损,Nogo-P3幅值降低是受损敏感指标。

关键词: 儿童, 肥胖, 注意认知, 主动抑制

Abstract: Objective To explore the relationship between childhood obesity and attention cognitive control through event-related potentials and behavioral monitoring using the cued target/non-target (Go/Nogo) task mode, in order to provide reference for early detection of attention problems in obese children. Methods A total of 38 obese children were selected from the obesity clinic of Changzhou Children′s Hospital from August 2019 to August 2021, and 41 normal children were selected from a primary school in Changzhou during the same period. A continuous performance test (CPT) was used to conduct electroencephalogram (EEG) tests, ERP and behavioral data were recorded and compared. Results At the behavioral level, compared with the normal group, the correct hits of obese children were significantly reduced [37(35, 39) vs. 39(38, 40), Z=-3.459, P=0.001)], and the reaction time was prolonged [(502.21±95.29) ms vs. (454.45±95.24) ms, t=2.210, P=0.030], and the variability of reaction time was higher [(147.74±50.15) ms vs. (105.89±44.87) ms, t=3.330, P=0.001]. There was no significant difference in the number of false reports between the two groups (P > 0.05). At the cognitive level, there was no significant difference in N2 amplitude and latency between the obesity group and normal group under Go and Nogo conditions. The P3 Nogo/Go effect of obese children was significantly weaker than that of the normal group, and the Nogo-P3 amplitude of obese children was significantly lower than that of the control group [(16.47±8.46) μV vs. (21.58±7.91) μV, t=-2.771, P=0.007]. Conclusions Obese individuals have cognitive impairment of continuous attention, which is manifested in the decrease of hit number and the increase of response variation at the behavioral level. The conflict monitoring ability of obese children is equivalent to that of normal children, but their active inhibition ability is impaired, with the decrease of Nogo-P3 amplitude as a sensitive index of impairment.

Key words: children, obesity, continuous attention, active inhibition

中图分类号:

R729

倪曼曼, 王超群, 汪莹莹, 董选, 董毓, 殷志萍, 沈惠娟. 学龄期肥胖儿童注意认知事件相关电位及行为学研究[J]. 中国儿童保健杂志, 2022, 30(12): 1371-1375.

NI Man-man, WANG Chao-qun, WANG Ying-ying, DONG Xuan, DONG Yu, YIN Zhi-ping, SHEN Hui-juan. Attention cognitive event-related potentials and behaviors of school-age obese children[J]. Chinese Journal of Child Health Care, 2022, 30(12): 1371-1375.

参考文献

[1] 陈贻珊, 张一民, 孔振兴, 等. 我国儿童青少年超重、肥胖流行现状调查[J]. 中华疾病控制杂志, 2017,21(9):866-869.
[2] Farruggia MC, Small DM. Effects of adiposity and metabolic dysfunction on cognition: A review[J]. Physiol Behav, 2019(208):112578.
[3] Alavi M, Seng JH, Mustaffa MS, et al. Attention, impulsiveness, and gender in academic achievement among typically developing children[J]. Percept Mot Skills, 2019,126(1):5-24.
[4] Mac GN, Swistun D, Murray S, et al. Executive dysfunction in depression in adolescence:The role of inflammation and higher body mass[J]. Psychol Med, 2020,50(4):683-691.
[5] Pan L, Li X, Feng Y, et al. Psychological assessment of children and adolescents with obesity[J]. J Int Med Res, 2018,46(1):89-97.
[6] Tarantino V, Vindigni V, Bassetto F, et al. Behavioral and electrophysiological correlates of cognitive control in ex-obese adults[J]. Biol Psychol, 2017(127):198-208.
[7] Tsai CL, Huang TH, Tsai MC. Neurocognitive performances of visuospatial attention and the correlations with metabolic and inflammatory biomarkers in adults with obesity[J]. Exp Physiol, 2017,102(12):1683-1699.
[8] 杜苏苏,彭璐婷,武苏,等.肥胖儿童青少年血清脂肪因子与其代谢特征的相关性研究[J].中国循证儿科杂志,2019,14(5):374-379.
[9] Barry RJ, De Blasio FM, Fogarty JS. A processing schema for children in the auditory equiprobable Go/Nogo task: ERP components and behaviour[J]. Int J Psychophysiol, 2018,123:74-79.
[10] Boucher O, Bastien CH, Muckle G, et al. Behavioural correlates of the P3b event-related potential in school-age children[J]. Int J Psychophysiol, 2010,76(3):148-157.
[11] Meo SA, Altuwaym AA, Alfallaj RM, et al. Effect of obesity on cognitive function among school adolescents: A cross-sectional study[J]. Obes Facts, 2019,12(2):150-156.
[12] Simmonds DJ, Fotedar SG, Suskauer SJ, et al. Functional brain correlates of response time variability in children[J]. Neuropsychologia, 2007,45(9):2147-2157.
[13] Burkhard A, Elmer S, Kara D, et al. The effect of background music on inhibitory functions: An ERP study[J]. Front Hum Neurosci, 2018,12:293.
[14] Niessen E, Ant JM, Bode S, et al. Preserved performance monitoring and error detection in left hemisphere stroke[J]. Neuroimage Clin, 2020,27:102307.
[15] Cheng CH, Tsai HY, Cheng HN. The effect of age on N2 and P3 components: A meta-analysis of Go/Nogo tasks[J]. Brain Cogn, 2019,135:103574.
[16] Brevers D, Cheron G, Dahman T, et al. Spatiotemporal brain signal associated with high and low levels of proactive motor response inhibition[J]. Brain Res, 2020,1747:147064.
[17] Cheng CH, Tsai HY, Cheng HN. The effect of age on N2 and P3 components: A meta-analysis of Go/Nogo tasks[J]. Brain Cogn, 2019(135):103574.
[18] Gajewski PD, Falkenstein M. Effects of task complexity on ERP components inGo/Nogo tasks[J]. Int J Psychophysiol, 2013,87(3):273-278.
[19] Kamijo K, Pontifex MB, Khan NA, et al. The association of childhood obesity to neuroelectric indices of inhibition[J]. Psychophysiology, 2012,49(10):1361-1371.
[20] Alatorre-Cruz GC, Downs H, Hagood D, et al. Effect of obesity on inhibitory control in preadolescents during stop-signal task. An event-related potentials study[J]. Int J Psychophysiol, 2021,165:56-67.
[21] Alonso-Alonso M, Pascual-Leone A. The right brain hypothesis for obesity[J]. JAMA, 2007,297(16):1819-1822.
[22] Chen S, Jia Y, Woltering S. Neural differences of inhibitory control between adolescents with obesity and their peers[J]. Int J Obes (Lond), 2018,42(10):1753-1761.
[23] Riggins T, Scott LS. P300 development from infancy to adolescence[J]. Psychophysiology, 2020,57(7):e13346.

学龄期肥胖儿童注意认知事件相关电位及行为学研究

Attention cognitive event-related potentials and behaviors of school-age obese children

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