关键词: 脑性瘫痪, 癫痫, 粗大运动功能分级

Abstract: Objective To analyze the association of high risk factors and clinical characteristics of cerebral palsy with epilepsy in children, and to explore the risk factors of epilepsy in children with cerebral palsy. Methods Data of children with cerebral palsy hospitalized in the Third Affiliated Hospital of Zhengzhou University from January 2019 to February 2022 were collected retrospectively, and the children were divided into two groups:cerebral palsy with epilepsy group and non-epilepsy group. The difference of high risk factors and clinical characteristics between the two groups was analyzed by χ² test, and multivariate Logistic regression was used to analyze the risk factors of common epilepsy. Results A total of 630 children with cerebral palsy were included, including 421 boys and 209 girls. There were 155 children with epilepsy in the cerebral palsy group and 475(24.6%) children in the non-epilepsy group. The prevalence rate of intrauterine distress, asphyxia, multiple births and congenital malformation in the cerebral palsy group were higher than those in the non-epilepsy group(χ²=4.788, 9.368, 5.255, 12.111, P＜0.05). There were significant differences in cerebral palsy classification, Magnetic Resonance Imaging Classification System(MRICS) and Gross Motor Function Classification System (GMFCS) between the two groups(χ²=213.686, 14.640, 481.531, P＜0.05). Spastic quadriplegia (OR=14.090, 95%CI:1.950 - 101.183), history of congenital malformation (OR=1.891, 95%CI:1.155 - 3.095) and history of asphyxia (OR=1.527, 95%CI:1.034 - 2.255) may be the risk factors of epilepsy in children with cerebral palsy (P<0.05). Conclusion Epilepsy in children with cerebral palsy is severe and had high prevalence rate, identifying risk factors can provide basis for targeted clinical treatment.

Key words: cerebral palsy, epilepsy, Gross Motor Function Classification