儿童热性惊厥与频繁夜间遗尿症的相关性研究

doi:10.11852/zgetbjzz2022-1022

中国儿童保健杂志 ›› 2023, Vol. 31 ›› Issue (2): 147-151.DOI: 10.11852/zgetbjzz2022-1022

儿童热性惊厥与频繁夜间遗尿症的相关性研究

毛艺¹, 沈佳瑶², 钟少根¹, 金星明¹, 马骏¹

1.上海交通大学医学院附属上海儿童医学中心发育行为儿科,上海 200127;
2.上海交通大学医学院附属上海儿童医学中心肾内科

收稿日期:2022-08-24 修回日期:2022-11-24 发布日期:2023-02-16 出版日期:2023-02-10
通讯作者: 马骏,E-mail:majun@shsmu.edu.cn
作者简介:毛艺(1999-),女,安徽人,在读硕士研究生,主要研究方向为发育行为儿科。
基金资助:
上海市2020年度“科技创新行动计划”自然科学基金项目(20ZR1434700);上海市2022年度“科技创新行动计划”医学创新研究专项项目(22Y11920100);上海市公共卫生体系建设三年行动计划(2011-2013)(11PH1951202)

Associations between febrile seizures and frequent nocturnal enuresis in children

MAO Yi¹, SHEN Jia-yao², ZHONG Shao-gen¹, JIN Xing-ming¹, MA Jun¹

1. Department of Developmental and Behavioral Pediatrics, Shanghai Children′s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;
2. Department of Nephrology, Shanghai Children′s Medical Center, School of Medicine, Shanghai Jiao Tong University

Received:2022-08-24 Revised:2022-11-24 Online:2023-02-10 Published:2023-02-16
Contact: MA Jun, E-mail:majun@shsmu.edu.cn

摘要/Abstract

摘要： 目的探讨儿童热性惊厥与频繁夜间遗尿症的关系,为遗尿症的危险因素提供研究依据,并分析在儿童不同年龄及性别中二者相关性的变化。方法用分层整群随机抽样的方法于2014年6月—2015年6月在上海市抽取3个市区和4个郊区,以5~12岁儿童为研究对象并分发问卷85 860份,采用多因素Logistic回归分析热性惊厥与频繁夜间遗尿症的关系,敏感性分析观察二者相关性在年龄和性别中的变化。结果上海市共有62 290名5~12岁儿童纳入研究。控制混杂因素后,多因素分析显示热性惊厥儿童患频繁夜间遗尿症的风险较高(OR=7.740,95%CI:5.512~10.870,P<0.001)。随着儿童年龄增加二者相关性越强(P<0.001),尤其在女童中(OR=13.798,95%CI:8.056~23.631,P<0.001)比男童(OR=4.422,95%CI:2.580~7.579,P<0.001)更为显著。结论热性惊厥与频繁夜间遗尿症显著相关,尤其在高年龄组与女童中更为显著,提示热性惊厥为频繁夜间遗尿症的危险因素之一。

关键词: 频繁夜间遗尿症, 热性惊厥, 儿童, 危险因素, 性别

Abstract: Objective To investigate the associations between febrile seizures and frequent nocturnal enuresis, so as to provide evidence for study of risk factors for enuresis and explore the changes of the associations in different ages and genders. Methods A stratified cluster random sampling method was used to select 85 860 children aged 5 to 12 years in 3 urban areas and 4 suburbs in Shanghai from June 2014 to June 2015, and children were asked to fill out questionnaire. Multivariate Logistic regression analysis was used to analyze the association between febrile seizures and frequent nocturnal enuresis. Sensitivity analysis was performed to observe the changes of association in ages and genders. Results Finally 62 290 valid questionnaires were enrolled in this study. Multivariate analysis showed that children with febrile seizures still had a high risk of enuresis after controlling for confounding factors (OR=7.740, 95%CI:5.512 - 10.870, P<0.001). In addition, the association between the two increased with ages (P<0.001), which was more significant in girls (OR=13.798, 95%CI:8.056 - 23.631, P<0.001) than boys (OR=4.422, 95%CI:2.580 - 7.579, P<0.001). Conclusion Febrile seizures is significantly associated with frequent nocturnal enuresis, especially in older age groups and girls, suggesting that FS is one of the risk factors for frequent nocturnal enuresis.

Key words: frequent nocturnal enuresis, febrile seizures, children, risk factors, gender

中图分类号:

R720.597

毛艺, 沈佳瑶, 钟少根, 金星明, 马骏. 儿童热性惊厥与频繁夜间遗尿症的相关性研究[J]. 中国儿童保健杂志, 2023, 31(2): 147-151.

MAO Yi, SHEN Jia-yao, ZHONG Shao-gen, JIN Xing-ming, MA Jun. Associations between febrile seizures and frequent nocturnal enuresis in children[J]. Chinese Journal of Child Health Care, 2023, 31(2): 147-151.

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儿童热性惊厥与频繁夜间遗尿症的相关性研究

Associations between febrile seizures and frequent nocturnal enuresis in children

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