关键词: 巨大儿, 瘦素, 脂联素, 胰岛素样生长因子-Ⅰ

Abstract: 【Objective】 To analyze the originated correlation factors of macrosomia as well as its correlation to obesity in Qingdao,to guide duration of pregnancy and offer accordance for monitoring postnatal growth development. 【Methods】 To observe 1 815 cases of macrosomia as observational group,to compare the pregestational BMI,weight gain during pregnancy,body height,'glycometabolism,investigating diet,exercise.The level of leptin,adiponectin,insulin-like growth factor-Ⅰin the cord blood of 80 cases (40 cases macrosomia,40 case normal) were measured by enzyme linked immunosorbent assay(ELISA).BMI were assessed at 6 growth development to monitoring time for macrosomia and AGA. 【Results】 The index of pregestational BMI,weight gain during pregnancy,body height,'glycometabolism in observational group were much more abnormal than those in control group,and the intake of seafood and fruit in diet,the level of leptin,insulin-like growth factor-Ⅰin the cord blood,incidence rate of the overweight by assessing the BMI at postnatal monitoring point were all higher than those in the control group,while the adiponectin and movement time were lower than those in the control group. 【Conclusions】 The pregestational BMI,weight gain during pregnancy,body height,`glycometabolism,diet and exercise of gravida are the reasons to result in macrosomia.Macrosomia has the same pathology fundament as adults obesity,their postnatal incidence rate of overweight raise up obviously.

Key words: macrosomia, leptin, adiponectin, insulin-like growth facto-Ⅰ