江苏省某县两岁幼儿双酚A暴露水平评估及影响因素分析

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (10): 1014-1017.

江苏省某县两岁幼儿双酚A暴露水平评估及影响因素分析

吕沈亮，邬春华，刘萍，张济明，常秀丽，周志俊

复旦大学公共卫生学院/教育部公共卫生安全重点实验室，上海 200032

收稿日期:2014-04-24 发布日期:2014-10-10 出版日期:2014-10-10
通讯作者: 邬春华,E-mail:chwu@shmu.edu.cn
作者简介:吕沈亮(1989-)，男，硕士研究生，研究方向为职业安全。
基金资助:
上海市自然科学基金资助项目(11ZR1402200)

Assessment of bisphenol A exposure and influencing factors among two-year-old children living in a county of Jiangsu province

LV Shen-liang,WU Chun-hua,LIU Ping,ZHANG Ji-ming,CHANG Xiu-li,ZHOU Zhi-jun

School of Public Health /MOE Key Lab for Public Health Safety,Fudan University,Shanghai 200032,China

Received:2014-04-24 Online:2014-10-10 Published:2014-10-10
Contact: WU Chun-hua,E-mail:chwu@shmu.edu.cn

摘要/Abstract

摘要： 目的评估2岁幼儿尿中双酚A(bisphenol A，BPA)水平和每日摄入量及其影响因素，为进一步研究BPA对幼儿健康影响提供基础数据。方法选取某县365名幼儿，由其父母完成问卷调查并协助幼儿采集尿样，测定尿中BPA含量，估算每日摄入量及分析影响因素。结果 BPA检出率为72.05%，可检出浓度范围为0.20～106.38 μg/L，肌酐未校正和校正后中位值分别为0.95 μg/L和2.96 μg/g。每日摄入量按肌酐估算最大值为4.596 μg/kg bw/24 h，低于欧盟食品安全机构(European Food Safety Authority，EFSA)提出的BPA每日允许摄入量(tolerable daily intake，TDI)。统计分析结果显示不同性别幼儿BPA水平相似，而不同居住地间BPA水平差异有统计学意义(P<0.05)。结论该地区2岁幼儿普遍暴露于BPA，暴露水平低于EFSA提出的TDI。

关键词: 双酚A, 尿, 2岁幼儿, 每日摄入量估算

Abstract: Objective To evaluate levels of urinary bisphenol A,daily intake and its influencing factors among two-year-old children. Methods Questionnaires and spot urine samples were collected from 365 children living in a county of Jiangsu province.Urinary BPA concentration was determined,daily intake was calculated and the influencing factors were identified. Results The detection rate of urinary BPA was 72.05%.The detectable range was 0.20~106.38 μg/L.The median value and the median value of BPA concentration with creatinine correction were 0.95 μg/L and 2.96 μg/g,respectively.The calculated maximum value of BPA daily intake was 4.596 μg/kg bw/24 h and was lower than the tolerable daily intake(TDI)in Europe.Statistical analysis indicated that the BPA concentrations were similar between female and male children.The locations of residence had statistically significant effects on concentrations (P<0.05). Conclusion The findings suggests that the two-year-old children are widely exposed to BPA in the studied county and the calculated daily intakes are lower than TDI in Europe.

Key words: bisphenol A, urine, two-year-old children, daily intake calculation

中图分类号:

R126

吕沈亮，邬春华，刘萍，张济明，常秀丽，周志俊. 江苏省某县两岁幼儿双酚A暴露水平评估及影响因素分析[J]. 中国儿童保健杂志, 2014, 22(10): 1014-1017.

LV Shen-liang,WU Chun-hua,LIU Ping,ZHANG Ji-ming,CHANG Xiu-li,ZHOU Zhi-jun. Assessment of bisphenol A exposure and influencing factors among two-year-old children living in a county of Jiangsu province[J]. journal1, 2014, 22(10): 1014-1017.

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