关键词: 社会交流, 社会互作奖赏剥夺, 条件性口味偏好, 代谢性学习记忆

Abstract: Objective To research the effects of social withdrawal on the metabolic learning and memory,to shed more lights on the relationship between social activities such as parent-child relationship,social isolation,collective life and feeding behaviors in children. Methods A total of 39 three-month-old male C57BL/6J mice were randomly divided into communally and lonely living groups,both of which were then subject to the conditioned flavor preference training using the metabolic energy as the unconditioned stimulus.As the feeding training was done in a single-living behavioral cage,where the communally but not lonely living mice would produce strong social withdrawal.The effects of social withdrawal on the metabolic learning and memory were assessed. Results Prior to conditioned flavor preference training,the social withdrawal group of mice drunk less flavored solution during the pre-test period compared with the control group,but had no significant preference over the two unconditioned flavors.After the conditioning,both groups of mice preferred to the flavor coupled with energy metabolism over the other one.However,the social withdrawal group of mice produced less flavor preference compared with control.During the entire training process,there were no significant changes in body weight of both groups of mice. Conclusion Social withdrawal indeed significantly affects feeding behavior,especially on the metabolic learning and memory in mice.The research emphasizes on the impact of proper social interaction for diet feeding behavior in children.

Key words: social interaction, social withdrawal, conditioned flavor preference, metabolic learning and memory