关键词: 极早产, 超早产, 生长, 体成分, 出院后强化喂养

Abstract: Objective To investigate the effects of different intensive feeding methods on catch-up growth of very preterm and extremely preterm infants (VPT/EPT) and body composition (BC) development,in order to provide theoretical support for the post-discharge healthcare of VPT/EPT. Methods Totally 91 VPT and EPTs followed up in the outpatient clinic of Children′s Hospital of Fudan University were enrolled in this study from April 2018 to October 2019,and were given individualized intensive feeding guidance.Physical examination and BC assessment were performed monthly after corrected gestational age of 40 weeks. Results Compared with partial breastfeeding and formula feeding groups,the breastfeeding group had a lower weight-for-age Z score at 4,5 and 6 months(P=0.042,0.033,0.037),a lower weight-for-length Z score at the age of 6 months (P=0.016).In terms of BC,the body fat percentage at the age of 4 months was significantly lower than that of partial breastfeeding and formula feeding groups (25% vs.28.1% vs.28.8%,P=0.015).And the fat-free mass index (FFMI) at the age of 6 months in the breastfeeding group was significantly higher than that in the formula feeding group (13.08 vs.11.78,P=0.034). Conclusions Breastfed VPT/EPT in early life may tend to have an impaired weight gain and body fat deposit.Further studies with larger cohorts and research on the long-term consequences of these early differences are warranted.

Key words: very preterm, extremely preterm, growth, body composition, intensive feeding after discharge