二十二碳六烯酸与认知功能发育研究进展

doi:10.11852/zgetbjzz2019-1674

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (11): 1227-1230.DOI: 10.11852/zgetbjzz2019-1674

二十二碳六烯酸与认知功能发育研究进展

王美辰¹, 石羽杰², 刘彪², 任中夏¹, 武薇¹, 张玉梅¹

1 北京大学公共卫生学院营养与食品卫生学系,北京 100191;
2 内蒙古伊利实业集团股份有限公司,内蒙古呼和浩特 010110

收稿日期:2019-12-05 修回日期:2020-01-09 发布日期:2020-11-10 出版日期:2020-11-10
通讯作者: 张玉梅,E-mail:zhangyumei@bjmu.edu.cn
作者简介:王美辰(1992-),女,山东人,博士在读,主要研究方向为人群营养
基金资助:
“十二五”国家科技支撑计划课题(2013BAD18B03)

Research advances on docosahexaenoic acid and cognition function deveolpment

WANG Mei-chen¹, SHI Yu-jie², LIU Biao², REN Zhong-xia¹, WU Wei¹, ZHANG Yu-mei¹

1 Department of Nutrition and Food Hygiene,School of Public Health,Peking University,Beijing 100191,China;
2 Inner Mongolia Yili Industrial Group Company Limited,Hohhot,Inner Mongolia 010110,China

Received:2019-12-05 Revised:2020-01-09 Online:2020-11-10 Published:2020-11-10
Contact: ZHANG Yu-mei,E-mail:zhangyumei@bjmu.edu.cn

摘要/Abstract

摘要： 二十二碳六烯酸(DHA)参与机体的多种生理功能,对生命早期大脑发育、机体的认知功能发育、视觉发育以及机体免疫功能具有重要作用。本文从DHA的来源及其对认知功能的作用进行综述,发现DHA对婴幼儿,特别是早产儿的大脑发育、认知功能发育、精神运动发育有积极作用。但随着年龄增加,对学龄儿童智力上的影响差异并无统计学意义。孕乳母及婴幼儿适量DHA的摄入对生命周期内大脑DHA水平的维持至关重要。

关键词: 二十二碳六烯酸, 婴幼儿, 认知功能

Abstract: Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid (LCPUFA) that has involved in various functions of life.It plays an important role in brain development,cognitive function and visual development,as well as the immune function of newborns.This article reviews the origins of DHA and its effects on cognitive function,and explores the effects of DHA intake on the development of cognitive function in preterm infants,infants and childhood.However,with the increase of age,there is no significant difference in the influence on the intelligence of school-age children. Appropriate DHA intake of pregnant,lactating mothers and infants is very important for the maintenance of brain DHA level in life cycle.

Key words: docosahexaenoic acid, infants, cognition

中图分类号:

:R153.2

王美辰, 石羽杰, 刘彪, 任中夏, 武薇, 张玉梅. 二十二碳六烯酸与认知功能发育研究进展[J]. 中国儿童保健杂志, 2020, 28(11): 1227-1230.

WANG Mei-chen, SHI Yu-jie, LIU Biao, REN Zhong-xia, WU Wei, ZHANG Yu-mei. Research advances on docosahexaenoic acid and cognition function deveolpment[J]. journal1, 2020, 28(11): 1227-1230.

参考文献

[1] Echeverria F,Valenzuela R,Hernandez-Rodas MC,et al.Docosahexaenoic acid (DHA),a fundamental fatty acid for the brain:new dietary sources[J].Prostaglandins Leukot Essent Fatty Acids,2017,124(1):1-10.
[2] Kawabata T,Kagawa Y,Kimura F,et al.Polyunsaturated fa tty acid levels in maternal erythrocytes of Japanese women during pregnancy and after Childbirth[J].Nutrients,2017,9(3):1-10.
[3] Brenna JT,Varamini B,Jensen RG,et al.Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide[J].Am J Clin Nutr,2007,85(6):1457-1464.
[4] Fu Y,Liu X,Zhou B,et al.An updated review of worldwide levels of docosahexaenoic and arachidonic acid in human breast milk by region[J].Public Health Nutr,2016,19(15):2675-2687.
[5] Kim H,Kang S,Jung BM,et al.Breast milk fatty acid composition and fatty acid intake of lactating mothers in South Korea[J].Br J Nutr,2017,117(4):556-561.
[6] Craddock JC,Neale EP,Probst YC,et al.Algal supplementation of vegetarian eating patterns improves plasma and serum docosahexaenoic acid concentrations and omega-3 indices:a systematic literature review[J].J Hum Nutr Diet,2017,30(6):693-699.
[7] Forsyth S,Gautier S,Salem N,et al.Dietary intakes of arachidonic acid and docosahexaenoic acid in early life-with a special focus on complementary feeding in developing countries[J].Ann Nutr Metab,2017,70(3):217-227.
[8] Mazzocchi A,D'oria V,De Cosmi V,et al.The role of lipids in human milk and infant formulae[J].Nutrients,2018,10(5):1-14.
[9] Nguyen LN,Ma D,Shui G,et al.Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid[J].Nature,2014,509(7501):503-506.
[10] Mcnamara RK,Carlson SE.Role of omega-3 fatty acids in brain development and function:potential implications for the pathogenesis and prevention of psychopathology[J].Prostaglandins Leukot Essent Fatty Acids,2006,75(4-5):329-349.
[11] Weiser MJ,Butt CM,Mohajeri MH.Docosahexaenoic acid and cognition throughout the lifespan[J].Nutrients,2016,8(2):1-40.
[12] 陈昂,林翠兰,徐康.配方奶粉添加长链多不饱和脂肪酸对早产儿大脑发育影响的Meta分析[J].热带医学杂志,2017,17(4):503-506.
[13] Koletzko B.Should women providing milk to their preterm infants take docosahexaenoic acid supplements?[J].Clin Perinatol,2017,44(1):85-93.
[14] Sabel KG,Strandvik B,Petzold M,et al.Motor,mental and behavioral developments in infancy are associated with fatty acid pattern in breast milk and plasma of premature infants[J].Prostaglandins Leukot Essent Fatty Acids,2012,86(4-5):183-188.
[15] Makrides M,Gibson RA,Mcphee AJ,et al.Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid:a randomized controlled trial[J].JAMA,2009,301(2):175-182.
[16] Collins CT,Gibson RA,Anderson PJ,et al.Neurodevelopmental outcomes at 7 years' corrected age in preterm infants who were fed high-dose docosahexaenoic acid to term equivalent:a follow-up of a randomised controlled trial[J].BMJ Open,2015,5(3):1-11.
[17] Almaas AN,Tamnes CK,Nakstad B,et al.Long-chain polyunsaturated fatty acids and cognition in VLBW infants at 8 years:an RCT[J].Pediatrics,2015,135(6):972-980.
[18] Shulkin M,Pimpin L,Bellinger D,et al.n-3 fatty acid supplementation in mothers,preterm infants,and term infants and childhood psychomotor and visual development:A systematic review and Meta-analysis[J].J Nutr,2018,148(3):409-418.
[19] Kim H,Kim H,Lee E,et al.Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age:results of the MOCEH cohort study[J].J Nutr,2017,16(1):1-10.
[20] Ramakrishnan U,Gonzalez-Casanova I,Schnaas L,et al.Prenatal supplementation with DHA improves attention at 5 y of age:a randomized controlled trial[J].Am J Clin Nutr,2016,104(4):1075-1082.
[21] Crozier SR,Sibbons CM,Fisk HL,et al.Arachidonic acid and DHA status in pregnant women is not associated with cognitive performance of their children at 4 or 6-7 years[J].Br J Nutr,2018,119(12):1400-1407.
[22] Brouwer-Brolsma EM,van De Rest O,Godschalk R,et al.Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age:The MEFAB birth cohort[J].Prostaglandins Leukot Essent Fatty Acids,2017,126(1):92-97.
[23] Taylor RM,Fealy SM,Bisquera A,et al.Effects of nutritional interventions during pregnancy on infant and child cognitive outcomes:a systematic review and Meta-analysis[J].Nutrients,2017,9(11):1-32.
[24] Gould JF,Treyvaud K,Yelland LN,et al.Seven-year follow -up of children born to women in a randomized trial of prenatal DHA supplementation[J].JAMA,2017,317(11):1173-1175.
[25] 房爱萍,陈偲,韩军花,等.婴幼儿配方食品中添加长链多不饱和脂肪酸的健康效益:系统综述[J].营养学报,2018,40(6):531-543.
[26] Jiao J,Li Q,Chu J,et al.Effect of n-3 PUFA supplementation on cognitive function throughout the life span from infancy to old age:a systematic review and meta-analysis of randomized controlled trials[J].Am J Clin Nutr,2014,100(6):1422-1436.
[27] Drover JR,Hoffman DR,Castaneda YS,et al.Cognitive function in 18-month-old term infants of the DIAMOND study:a randomized,controlled clinical trial with multiple dietary levels of docosahexaenoic acid[J].Early Hum Dev,2011,87(3):223-230.
[28] Crawford MA,Wang Y,Forsyth S,et al.The European Food Safety Authority recommendation for polyunsaturated fatty acid composition of infant formula overrules breast milk,puts infants at risk,and should be revised[J].Prostaglandins Leukot Essent Fatty Acids,2015,102-103(1):1-3.

二十二碳六烯酸与认知功能发育研究进展

Research advances on docosahexaenoic acid and cognition function deveolpment

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