类固醇激素与孤独症谱系障碍的相关性研究进展

doi:10.11852/zgetbjzz2021-0747

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)是一类起源于婴幼儿时期的神经发育障碍性疾病。类固醇激素可能通过影响儿童的神经-精神发育而参与ASD发病。本文对常见的类固醇激素与ASD之间关系作一综述。

关键词: 类固醇激素, 孤独症谱系障碍, 皮质醇, 雌激素, 孕激素, 雄激素, 维生素D

Abstract: Autism spectrum disorder(ASD) is a neuropsychiatric developmental disorder that begins in infancy and childhood. Steroid hormones may result in the onset of ASD by affecting neuropsychiatric development. This article reviews the relationship between common steroid hormones and ASD.

Key words: steroid hormone, autism spectrum disorder, cortisol, estrogen, progesterone, male hormone, vitamin D

中图分类号:

R749.94

何青, 徐磊, 谢江. 类固醇激素与孤独症谱系障碍的相关性研究进展[J]. 中国儿童保健杂志, 2022, 30(11): 1221-1225.

HE Qing, XU Lei, XIE Jiang. Research progress on the relationship between steroid hormones and autism spectrum disorder[J]. Chinese Journal of Child Health Care, 2022, 30(11): 1221-1225.

参考文献

[1] Alok KS, Nandini G, Pooja PK, et al. Cell transplantation as a novel therapeutic strategy for autism spectrum disorders:A clinical study[J]. Am J Stem Cells, 2020, 9(5):89-100.
[2] Maenner MJ, Shaw KA, Baio J, et al. Prevalence of autism spectrum disorder among children aged 8 years-Autism and developmental disabilities monitoring network, 11 Sites, United States, 2016[J]. MMWR Surveill Summ, 2020, 69(4):1-12.
[3] 罗靓尹, 曹牧青, 石碧君, 等. 孤独症谱系障碍男童皮质醇分泌水平及其相关因素研究[J]. 教育生物学杂志, 2020, 8(1):18-22.
[4] Baker EK, Richdale AL, Hazi A, et al. Assessing a hyperarousal hypothesis of insomnia in adults with autism spectrum disorder[J]. Autism Res, 2019, 12(6):897-910.
[5] Gasser BA, Kurz J, Dick B, et al. Steroid metabolites support evidence of autism as a spectrum[J]. Bahav Sci(Basel),2019,9(5):52.
[6] 谢巧珍. 头发中皮质醇的质谱检测及其与孤独症儿童行为的关联[D].南京:东南大学.2011.
[7] Pan Z, Granger DA, Guérin NA, et al. Replication pilot trial of therapeutic horseback riding and cortisol collection with children on the autism spectrum[J]. Front Vet Sci, 2018, 5: 312.
[8] 马菲,任亮,陈素环.1～4岁孤独症患儿血清性激素水平变化的病例对照研究[J].中国校医,2020,34(2):111-113.
[9] 章素芳.孤独症患儿与正常儿童血清性激素水平对照研究[J].当代医学,2017,23(30):30-32.
[10] Elbaz F, Hamza RT, Ayad MS, et al. Hyperandrogenemia in male autistic children and adolescents:Relation to disease severity[J]. Int J Adolesc Med Health, 2014, 26(1):79-84.
[11] 陈冬梅, 邱久军, 周利冰, 等. 孤独症男童社交技能特点与睾酮水平的关系[J]. 中国妇幼健康研究, 2019, 30(3):278-281.
[12] 席波, 李军, 孙付胜, 等. 济南市部分10~13岁儿童唾液性激素水平与智力,人格的相关研究[J]. 预防医学论坛, 2006, 12(2):136-136.
[13] Owens SJ, Weickert TW, Purvestyson TD, et al. Sex-specific associations of androgen receptor CAG trinucleotide repeat length and of raloxifene treatment with testosterone levels and perceived stress in schizophrenia[J]. Mol Neuropsychiatry, 2019, 5(1):28-41.
[14] Terloyeva D, Frey AJ, Park BY, et al. Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort[J]. Mol Autism, 2020, 11(1):93.
[15] Vanderweiden RM, Helmerhorst FM, Eriksson T. Gonadotropin-releasing hormone agonist against severe aggression in autism[J]. BMJ Case Rep,2016,2016:bcr2016216378.
[16] Pivovarciova A, Durdiakova J, Babinska K, et al. Testosterone and androgen receptor sensitivity in relation to hyperactivity symptoms in boys with autism spectrum disorders[J]. PLoS One, 2016, 11(2):e0149657.
[17] 郑湃. 婴儿出生前后性激素水平与孤独症的关系[J]. 中华预防医学杂志, 2014,48(3):185-185.
[18] Corbett BA, Schupp CW. The cortisol awakening response(CAR) in male children with autism spectrum disorder[J]. Horm Behav, 2014, 65(4):345-350.
[19] Park BY, Lee BK, Burstyn I, et al. Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study[J]. Mol Autism, 2017, 8: 3.
[20] Cherskov A, Pohl A, Allison C, et al. Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory[J]. Transl Psychiatry, 2018, 8(1):136.
[21] Lu Y, Sareddy GR, Wang J, et al. Neuron-derived estrogen regulates synaptic plasticity and memory[J]. J Neurosci, 2019, 39(15):2792-2809.
[22] Filice F, Lauber E, Vörckel KJ, et al. 17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms[J].Mol Autism,2018(9):15.
[23] 李骄阳,赖肖,肖新华,等.南昌市行为问题儿童血清双酚A、性激素水平调查[J].中国儿童保健杂志,2017,25(12):1274-1277.
[24] Crider A, Thakkar R, Ahmed AO, et al. Dysregulation of estrogen receptor beta(ERβ), aromatase(CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects[J]. Mol Autism, 2014, 5(1):46.
[25] 邢玉,邓红珠,陈凯云,等.子代孤独症与母亲基础性激素水平的关联性[J].中华行为医学与脑科学杂志,2015,24(3):218-221.
[26] Cheryl AF, Danielle CL. Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice[J]. Physiol Behav, 2010, 100(3):264-267.
[27] Janšáková K, Hill M, Čelárová D, et al. Alteration of the steroidogenesis in boys with autism spectrum disorders[J]. Transl Psychiatry, 2020, 10(1):340.
[28] 柯晓殷, 张英, 寇聪, 等. 孤独谱系障碍治疗前后血清性激素水平研究[J]. 中国神经精神疾病杂志, 2015, 41(9):569-572.
[29] 邢晓曼. 高频rTMS刺激Broca区配合康复训练治疗ASD患儿疗效及对儿童行为,心理发育的影响[J]. 中国疗养医学, 2018,27(7):721-723.
[30] Li L, Li M, Lu J, et al. Prenatal Progestin exposure is associated with autism spectrum disorders[J]. Front Psychiatry, 2018(9):611.
[31] Patricia MW, Marci L. Low maternal progesterone may contribute to both obstetrical complications and autism[J]. Med Hypotheses, 2014, 82(3):313-318.
[32] Zhu J, Guo M, Yang T, et al. Nutritional status and symptoms in preschool children with autism spectrum disorder: A two-center comparative study in Chongqing and Hainan Province, China[J]. Front Pediatr, 2020(8):469.
[33] Şengenç E, Kıykım E, Saltik S. Vitamin D levels in children and adolescents with autism[J]. J Int Med Res, 2020, 48(7):300060520934638.
[34] Chen L, Shi XJ, Liu H, et al. Oxidative stress marker aberrations in children with autism spectrum disorder: A systematic review and meta-analysis of 87 studies(N=9109)[J]. Transl Psychiatry, 2021, 11(1):15.
[35] Vuillermot S, Luan W, Meyer U, et al. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation[J]. Mol Autism, 2017, 8: 9.
[36] Fernell E, Bejerot S, Westerlund J, et al. Autism spectrum disorder and low vitamin D at birth: A sibling control study[J]. Mol Autism, 2015, 6: 3.
[37] Vinkhuyzen A, Eyles DW, Burne T, et al. Gestational vitamin D deficiency and autism-related traits: The Generation R Study[J]. Mol Psychiatry, 2018, 23(2):240-246.
[38] Brian K L, Darryl WE, Cecilia M, et al. Developmental vitamin D and autism spectrum disorders: Findings from the Stockholm Youth Cohort[J].Mol Psychiatry, 2021, 26(5):1578-1588.
[39] Ali AA, Cui X, Pertile R, et al. Developmental vitamin D deficiency increases foetal exposure to testosterone[J]. Mol Autism, 2020, 11(1):96.
[40] Ali A, Vasileva S, Langguth M, et al. Developmental Vitamin D deficiency produces behavioral phenotypes of relevance to autism in an animal model[J]. Nutrients, 2019, 11(5):1187.
[41] Lee JH, Espinera AR, Chen D, et al. Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats[J]. J Neuroinflammation, 2016, 13(1):109.
[42] Cannell JJ. Autism and vitamin D[J]. Med Hypotheses, 2008, 70(4):750-759.
[43] 张迎黎, 贾福军, 郭新胜, 等. 抑郁症患者治疗前后性激素水平的变化及与临床特征的关系[J]. 上海精神医学, 2003, 15(4):222-224.
[44] Brzezinski A. Schizophrenia and sex hormones: What is the link?[J]. Front Psychiatry, 2020(11):693.
[45] 李金, 张晓斌, 肖文焕, 等. 长期住院男性精神分裂症患者睾酮水平与认知功能的关系[J]. 国际精神病学杂志,2019,46(4):641-643,647.
[46] 邱久军, 陈冬梅, 周利冰,等. 孤独症谱系障碍男童共情能力特点以及与睾酮水平的关系[J]. 中国实用医药, 2018,13(21):13-16.