中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (4): 403-404.DOI: 10.11852/zgetbjzz2014-22-04-20

• 临床研究与分析 • 上一篇    下一篇

婴幼儿哮喘与支气管哮喘的遗传相关性研究

徐婕, 刘长云, 李俊杰, 范蒙蒙, 丁宝栋   

  1. 潍坊医学院, 山东 潍坊 261000
  • 收稿日期:2013-11-19 发布日期:2014-04-10 出版日期:2014-04-10
  • 通讯作者: 刘长云, E-mail:changyun1@163.com
  • 作者简介:徐婕(1988-), 女, 在读硕士研究生, 主要研究方向为遗传与优生。

Study on genetic correlation between infant asthma and bronchial asthma.

XU Jie, LIU Chang-yun, LI Jun-jie, FAN Meng-meng, DING Bao-dong.   

  1. Weifang Medical University, Weifang, Shandong 261000, China
  • Received:2013-11-19 Online:2014-04-10 Published:2014-04-10
  • Contact: LIU Chang-yun, E-mail:changyunl@163.com

摘要: 目的 探讨婴幼儿哮喘及支气管哮喘的遗传方式, 观察两者的遗传相关性, 为哮喘的三级预防提供理论依据。方法 通过Falconer回归法估计婴幼儿哮喘与支气管哮喘的遗传度, Logistic回归分析总结两者的主要危险因素, S-N-K法方差分析进行比较。结果 婴幼儿哮喘的遗传度为(80.53±7.85)%, 支气管哮喘的遗传度为(78.87±6.99)%, 两者危险因素比较无统计学意义(P>0.05)。结论 遗传因素在哮喘的发生、发展中起主要作用, 其他危险因素起协同作用, 两者具有密切相关性。因此预防婴幼儿哮喘, 可以有效的减少和预防支气管哮喘的发生。

关键词: 婴幼儿哮喘, 支气管哮喘, 遗传度, Logistic回归分析

Abstract: Objective To explore the mode of inheritance and genetic correlation was observed between the two of infant asthma and bronchial asthma, and provide a theoretical basis for the three grade prevention of asthma. Method Through the Falconer regression method to estimate the heritability of infant asthma and bronchial asthma, Logistic regression analysis of the major risk factors was summarized, S-N-K method were compared. Results The heritability for infants with asthma was (80.53±7.85)%, the heritability of bronchial asthma was (78.87±6.99)%.There was no significant difference between the two risk factors. Conclusion Genetic factors play a major role in the onset and development of asthma, other risk factors play a role, both have close correlation.Therefore, prevention of asthma in infants and young children can effectively reduce and prevent the occurrence of asthma.

Key words: infant asthma, bronchial asthma, heritability, Logistic regression analysis

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