关键词: 小于胎龄儿, 矮小症, 重组人生长激素

Abstract: Objective To investigate the clinical value of small for gestational age (SGA) children with short stature rhGH treatment and the appropriate course of treatment,comparing SGA groups height growth and normal groups differences. Methods A total of 526 children of SGA born from 2000 to 2006 were observed,and 88 cases of SGA children with short stature were divided into treatment group with 34 children and control group with 54 children.rhGH treatment was administered in the treatment group.And the efficacy of height growth during 6 months,1 year,1.5 years,2 years were compared.All of 526 SGA children's height growth were being monitored for two years. Results After two years observed,31 cases (91.2%) of treatment group had an effective catch-up growth,however,only 5 cases (9.3%) of control group had an effective catch-up growth (P<0.01).RhGH efficacy of different treatment period was different (P<0.01).But there was no statistically significant differences (P=0.45) compared with 1.5 years treatment and 2 years treatment.Height growth characteristics of the entire SGA groups,except for the impact of rhGH treatment,most individuals were carried at the growth of the growth curve trajectory height compared to the normal population of the SGA groups obviously partial short. Conclusions RhGH treatment can effectively promote SGA children with short stature accelerated height growth,the treatment costs and benefit were the highest at therapeutic doses days 0.15 U/kg with the 1.5 years treatment.SGA height of the entire group compared to the normal was population obviously partial short,trends was unable to reverse over time after two years of monitoring .

Key words: small for gestational age children, short stature, recombinant human growth hormone