中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (6): 623-626.DOI: 10.11852/zgetbjzz2015-23-06-20

• 临床研究与分析 • 上一篇    下一篇

黑色素皮质激素第四受体基因rs17782313与儿童肥胖相关性的Meta分析

周玲玲,张刚   

  1. 南京医科大学附属南京儿童医院,江苏 南京 210008
  • 收稿日期:2014-09-11 发布日期:2015-06-10 出版日期:2015-06-10
  • 通讯作者: 张刚,E-mail:xiaogangayy@126.com
  • 作者简介:周玲玲(1986-),女,安徽人,本科学历,主要从事小儿护理工作。

Association between MC4R rs17782313 polymorphism and childhood obesity:a Meta-analysis

ZHOU Ling-ling,ZHANG Gang   

  1. Nanjing Children's Hospital Affliated to Nanjing Medical University,Nanjing,Jiangsu 210008,China
  • Received:2014-09-11 Online:2015-06-10 Published:2015-06-10
  • Contact: ZHANG Gang,E-mail:xiaogangyaryy@126.com

摘要: 目的 应用Meta分析系统评价黑色素皮质激素第四受体基因(melanocortin-4 receptor gene,MC4R) rs17782313与儿童肥胖易感性的关系,以得到更有说服力的结论。方法 利用计算机检索数据库PubMed,中国知网、万方等,手工检索纳入文献的参考文献。采用STATA 11.0软件进行Meta分析。利用随机效应模型或固定效应模型计算其合并比值比(OR)和95%可信区间(95%CI),以及合并加权均数差(WMD)的值。结果 共有12个研究纳入研究,其中在纯合子模型(OR=1.84,95%CI:1.44~2.36,Phet=0.001)、杂合子模型(OR=1.48,95%CI:1.29~1.70,Phet=0.756)、显性模型(OR=1.67,95%CI:1.39~1.99,Phet=0.082)和隐性模型(OR=1.35,95%CI:1.19~1.55,Phet=0.000),差异均有统计学意义。在基因型与体质指数(body mass index,BMI)Z-score定量关联性分析中,发现rs17782313T>C的突变会影响儿童的BMI Z-score(WMD=0.14,95%CI:0.06~0.23,CC vs TT)。结论 Meta分析研究结果证实了MC4R rs17782313与儿童肥胖的关系。

关键词: MCR4, 基因多态性, 儿童, 肥胖, Meta分析

Abstract: Objective To apply a Meta-analysis of various studies from different ethnic populations and assess the association of the melanocortin 4 receptor(MC4R) polymorphism with childhood obesity. Methods All published literature were retrieved that investigated association of MC4R variants with obesity from PubMed,CNKI and Wanfang database.Pooled odds ratio (OR) with 95% confidence interval (CI) and weighted mean difference (WMD) were calculated using fixed- or random-effects model. Results A total of 12 case-control studies were eligible for this analysis.Meta-analysis showed that MC4R rs17782313 increased the risk of childhood obesity in all models (CC vs TT,OR=1.84,95%CI:1.44~2.36;CC vs CT,OR=1.48,95%CI:1.29~1.70,Phet=0.756;CC vs TT/TC,OR=1.67,95%CI:1.39~1.99;TC/CC vs TT,OR=1.35,95%CI:1.19~1.55).Moreover,the association between genotypes and childhood the body mass index (BMI) Z-score was also significant (WMD=0.14,95%CI:0.06~0.23,CC vs TT). Conclusion The present meta-analysis confirms the association of MC4R polymorphism with risk of childhood obesity.

Key words: melanocortin 4 receptor, polymorphism, children, obesity, Meta-analysis

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