孤独症谱系障碍的神经免疫学研究进展

doi:10.11852/zgetbjzz2015-23-09-19

摘要/Abstract

摘要： 孤独症谱系障碍(autism spectrum disorder,ASD)是一组以持续的社会沟通及社会交往缺失和限制性的、重复的行为模式为特征的疾病谱。ASD病因及发病机制至今不明,宫内感染和出生后神经系统发育早期多种感染后可造成ASD发病的增加。病理学与血清学研究结果表明在ASD患者中神经免疫细胞、免疫分子和免疫系统相关基因存在分布、数量和结构的异常,而引起神经免疫功能失调和异常激活的免疫应答。目前神经免疫系统功能紊乱被认为可能与ASD发病存在明显相关性。亦有免疫治疗研究有效的报道。本综述立足于ASD神经免疫学领域研究,介绍了ASD的免疫学治疗方法,为ASD的治疗提供了新的思路。

关键词: 孤独症谱系障碍, 神经免疫学, 发病机制, 免疫治疗

中图分类号:

:R749.94

朱静综述, 唐久来审校. 孤独症谱系障碍的神经免疫学研究进展[J]. 中国儿童保健杂志, 2015, 23(9): 956-958.

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