关键词: 早产儿, 真菌, 败血症, 氟康唑

Abstract: Objective To investigate the clinical characteristics and pathogens and risk factors of fungal sepsis in preterm neonates and provide evidence for early diagnosis and treatment. Methods All preterm infants from May 2012 to May 2015 were selected.Pathogens and clinical features were observed and analyzed,and the outcomes were recorded. Results A total of 2 534 cases were admitted.Among the 23 infants diagnosed with positive blood,14 were very low birth weight (VLBW) infants and 5 were extremely low birth (ELBW) infants.Compared with the preterm infants without fungal sepsis,low birth weight,small gestational age,venous catheter and long-term parenteral nutrition were the risk factors.23 cases of fungal sepsis were due to Candidiasis,including 16 (69.6%) Candida parapsilosis,6 (26.1%) Candida albicans,1 (4.3%)Candida nameless.All of the Candidiasis were sensitive to Fluconazole. Conclusion VLBW/ELBW preterm infants are susceptible of fungal septicemia.Venous catheter and long-term parenteral nutrition are the risk factors.The full treatment course can improve the prognosis.

Key words: premature infant, fungal, septicemia, fluconazole