中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (1): 14-17.DOI: 10.11852/zgetbjzz2017-25-01-05

• 科研论著 • 上一篇    下一篇

四城市剖宫产与学龄期儿童哮喘发病相关性研究

陈云晓1,Erigene Rutayisire1,伍晓艳1,2,黄锟1,2,于伟平3,陈尚徽4,叶和义5,张安慧6,陶芳标1,2   

  1. 1 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,安徽 合肥 230032;
    2 安徽人口健康与优生省级
    实验室,安徽 合肥 230032;
    3 扬州大学医学院附属医院扬州市妇幼保健院儿童保健科,江苏 扬州 225002;
    4 铜陵市妇幼保健院保健科,安徽 铜陵 244000;
    5 安庆市妇幼保健所妇产科,安徽 安庆 246000;
    6 芜湖市疾病控制中心信息管理科,安徽 芜湖 241000
  • 收稿日期:2016-05-23 发布日期:2017-01-10 出版日期:2017-01-10
  • 通讯作者: 陶芳标,E-mail:fbtao@126.com
  • 作者简介:陈云晓(1991-),女,安徽人,初级职称,硕士研究生,主要从事学龄前儿童健康的研究。
  • 基金资助:
    国家自然科学基金(81373012)

Association between cesarean section and the risk of childhood asthma among preschool children in 4 cities.

CHEN Yun-xiao1,Erigene Rutayisire1,WU Xiao-yan1,2,HUANG Kun1,2,
YU Wei-ping3,CHEN Shang-hui4,YE He-yi5,ZHANG An-hui6,TAO Fang-biao1,2   

  1. 1 Department of Maternal,Child & Adolescent Health,School of Public Health,Anhui Medical University,Hefei,Anhui 230032 China;
    2 Anhui Provincial Key Laboratory of Population Health & Aristogenics,Hefei,Anhui 230032,China;
    3 Maternal and Child Health Care Hospital of Yangzhou,Affiliated Hospital of Medical College Yangzhou University,Yangzhou,Suzhou 225002,China;
    4 Maternal and Child Health Care Hospital of Tongling,Tongling,Anhui 244000,China;
    5 Maternal and Child Health Care Hospital of Anqing,Anqing,Anhui 246000,China;
    6 Maternal and Child Health Care Hospital of Wuhu,Wuhu,Anhui 241000,China.Corresponding author:TAO Fang-biao,E-mail:fbtao@126.com
  • Received:2016-05-23 Online:2017-01-10 Published:2017-01-10
  • Contact: TAO Fang-biao,E-mail:fbtao@126.com

摘要: 目的 分析剖宫产与学龄前儿童哮喘的关联,总结剖宫产与儿童哮喘的相关性,指导临床及孕产妇对剖宫产的认识。方法 选取安庆、芜湖、铜陵、扬州4个城市共8 900名3~6岁儿童作为研究对象。通过对儿童带养者问卷调查的形式收集儿童出生方式、哮喘患病情况、人口学资料和体格测量资料等。哮喘病例由县级以上医院确诊,孕妇分娩方式分为阴道分娩、医学指征剖宫产和选择剖宫产。运用多分类Logistic回归分析剖宫产与学龄前儿童哮喘的关联。结果 8 900名学龄前儿童中,剖宫产率为67.3%,哮喘患病率为7.0%,哮喘儿童中28.5%出生于自然分娩,71.5%出生于剖宫产。在控制地区、性别、早产、母亲怀孕年龄、父母文化程度、母乳喂养和儿童BMI后,医学指征剖宫产与学龄前儿童哮喘相关联(OR=1.25,95%CI1.03~1.52,P<0.05),而选择性剖宫产与学龄前儿童哮喘的关联无统计学意义(OR=1.19,95%CI0.94~1.51,P>0.05)。结论 剖宫产和学龄前儿童哮喘有关联,并且医学指征剖宫产会增加儿童哮喘发生的风险。

关键词: 哮喘, 剖宫产, 儿童, 学龄前

Abstract: Objective To examine the association between cesarean section (CS) and the risk of childhood asthma in preschool children. Methods A total of 8 900 children aged from 3 to 6 years old were recruited in Anqing,Wuhu,Tongling and Yangzhou.Data on the mode of delivery,asthma and potential confounders for the present study were obtained by questionnaires completed by the parents or the people who raised the children.All asthma cases were diagnosed by major hospitals.Mode of delivery was classified into vaginal delivery,elective CS and emergency CS.Multivariate logistic regression was used for statistical analyses. Results Of 8 900 preschool children,67.3% were born by cesarean section.The overall prevalence of asthma in the present cross-sectional study was 7.0%,within these children 28.5% were delivered vaginally while 71.5% were delivered by CS.After adjusting for region,sex,preterm birth,maternal age,parental education level,breastfeeding,child body mass index (BMI),children delivered by emergency CS had an increased risk of childhood asthma (OR=1.25,95%CI:1.03~1.52,P<0.05) compared to those delivered vaginally.However,no significant but elevated (OR=1.19,95%CI:0.94~1.51,P>0.05) higher odds of asthma was found in children delivered by elective CS compared to those delivered vaginally. Conclusion Emergency CS increased the risk of childhood asthma in preschool age.

Key words: asthma, cesarean section, children, preschool

中图分类号: