关键词: 新生儿感染, 多肽, 肺炎, 败血症, 坏死性小肠结肠炎

Abstract: Neonatal infection,especially among very-low-birth-weight preterm infants,is a significant cause of neonatalmorbidity and mortality.Their immune system is immaturity rendering them vulnerable to the invasion of pathogens,causing different infectious diseases.In China,infectious pneumonia is the most common in neonatal infectious disease,followed by sepsis and intestinal infection.Due to potent broad-spectrum antimicrobial activity and evolutionarily conservedin a variety of organisms of peptides,they have attracted extensive attentions of researchers.Several studies have confirmed the anti-infection effect and functional against microbes with antibiotic resistance of peptides in neonate.Based on these properties,they are expected to become future therapeutics for neonatal infection.This review addresses the developments of the main peptides in neonatal infectious disease including infectious pneumonia,sepsis and necrotizing enterocolitis.

Key words: neonatal infection, polypeptide;pneumonia, sepsis, necrotizing enterocolitis