中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (11): 1131-1133.DOI: 10.11852/zgetbjzz2017-25-11-14

• 综述与讲座 • 上一篇    下一篇

软骨生长板相关因素调控生长的研究进展

王盼盼1,邵倩2,班博2   

  1. 1 济宁医学院,山东 济宁 272067;
    2 济宁医学院附属医院内分泌科,山东 济宁 272029
  • 收稿日期:2017-09-04 出版日期:2017-11-10 发布日期:2017-11-10
  • 通讯作者: 班博,E-mail:banbo2011@163.com
  • 作者简介:王盼盼(1990-),女,山东人,硕士研究生,主要研究方向为下丘脑-垂体疾病。
  • 基金资助:
    山东省自然科学基金培养基金项目(ZR2014HP058)

Research progress on growth regulation of cartilage growth plate

WANG Pan-pan1,SHAO Qian2,BAN Bo2   

  1. 1 Jining Medical University,Jining,Shandong 272067,China;
    2 Department of Endocrinology, Affiliated Hospital of Jining Medical University,Jining,Shandong 272029,China
  • Received:2017-09-04 Online:2017-11-10 Published:2017-11-10
  • Contact: BAN Bo,E-mail:banbo2011@163.com

摘要: 软骨生长板(CGP)主要由软骨细胞及细胞外基质(ECM)构成。软骨细胞的增殖、分化、肥大及ECM的形成,是骨骼发育、线性生长的关键。因此,与CGP相关、调控生长的因素主要涉及作用于软骨细胞的生长激素-胰岛素样生长因子-1(GH-IGF-1)轴、多种激素、旁分泌因子、炎性细胞因子等及软骨ECM中的胶原蛋白、非胶原糖蛋白、蛋白聚糖等成分。既往对调控生长的研究主要集中在GH-IGF-1轴上,但近年来,GH-IGF-1轴之外、CGP上可调控生长的其他相关因素备受关注。

关键词: 生长板, 软骨细胞, 软骨细胞外基质, 调控, 生长

Abstract: Cartilage growth plate (CGP) is mainly composed of chondrocytes and extracellular matrix (ECM).The proliferation,differentiation,hypertrophy of chondrocytes,and the formation of ECM,are the key to the development of bone and linear growth.Therefore,the factors related to CGP that regulation growth mainly include growth hormone-like insulin-like growth factor-1 (GH-IGF-1) axis,various hormones,paracrine factors and inflammatory cytokines acting on chondrocytes and collagen in cartilage ECM,non-collagen glycoprotein,proteoglycan and other ingredients.Previous studies mostly focused on the regulation of GH-IGF-1 axis growth,but other relevant factors on CGP beyond GH-IGF-1 axis that can control the growth receives more concern in recent years.

Key words: growth plate, chondrocytes, extracellular matrix, regulation, growth

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