关键词: 枸橼酸咖啡因, 氨茶碱, 早产儿呼吸暂停, 早产儿, 神经发育

Abstract: Objective To compare the clinical efficacy of caffeine citrate and aminophylline in the treatment of primary apnea premature infants,and to evaluate the effect of caffeine and aminophylline on children's neurodevelopment. Methods A total of 50 cases with primary apnea using aminophylline treatment were randomly assigned to aminophylline group,and 34 cases using caffeine citrate treatment were assigned to caffeine group.Children in two groups both received regular follow-up in out-patient of high-risk infants.The clinical efficacy of the two groups was compared and BSID was used to assess the neurodevelopment at the corrected age of 6 months. Results The duration of NCPAP,invasive mechanical ventilation,oxygen and treatment in caffeine citrate treatment group was significantly lower than those of amiophylline treatment group (P<0.05),The scores of psychomotor developmental index (PDI) and mental developmental index (MDI) in citrate caffeine group at corrected age of 6 months were significantly higher than those in aminophylline treatment group (P<0.05). Conclusion The effect of caffeine citrate in treatment of primary apnea is better than that of aminophylline,and it has a certain effect on promoting long-term neurodevelopment.

Key words: caffeine citrate, aminophylline, apnea of prematurity, premature infant, neurodevelopment