关键词: 细菌, 重症肺炎, 多重耐药菌, 危险因素, 儿童

Abstract: Objective To analyze the related factors of multiple drug resistant bacteria infection in children with severe bacterial pneumonia. Methods A retrospective analysis was conducted from January 2011 to November 2015 to collect clinical data of 457 cases of children with bacterial severe pneumonia including 96 cases of multi drug resistant bacteria infection patients and 361 cases of non multi drug resistant bacteria infection of difference.Related factors analyzed by multivariate Logistic regression analysis. Results A total of 96 patients were with multi drug resistant strains of bacteria,including 68 males,28 females,aged 0~14 years old,and the average age was(6.09±4.51) years old.And 361 patients were without multi-drug resistant strains of bacteria,including 228 males,133 females,the average age was (5.34±4.63) years old.Multifactors analysis showed that the previous use of antimicrobial agents[OR=1.093,95%CI(1.014~1.179)],in PICU days [OR=3.613,95%CI(1.874~6.969)],and traumatic treatment after infection [OR=2.296,95%CI(1.141~4.619)],combined application of antibiotics [OR=6.861,95%CI(3.510~13.409)],antibiotic use days after infection [OR=1.295,95%CI(1.125~1.409)] were the main factors of multi drug resistant bacteria infection in children with severe bacterial pneumonia (P<0.05). Conclusion Effective measures should be taken to prevent and reduce the multiple drug resistant bacteria infection in children with bacterial pneumonia.

Key words: bacteria, severe pneumonia, multi-drug resistant bacteria, risk factors, children