左旋肉碱在儿童孤独症谱系障碍中的疗效分析

doi:10.11852/zgetbjzz2019-0124

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (9): 1015-1018.DOI: 10.11852/zgetbjzz2019-0124

左旋肉碱在儿童孤独症谱系障碍中的疗效分析

吕楠¹, 李东晓², 尚清¹, 马彩云¹, 李靖婕¹

1 郑州大学附属儿童医院河南省儿童医院郑州儿童医院康复中心,河南郑州 450053;
2 郑州大学附属儿童医院河南省儿童遗传代谢性疾病重点实验室,河南郑州 450018

收稿日期:2019-01-29 发布日期:2019-09-10 出版日期:2019-09-10
通讯作者: 尚清,E-mail:sqing1965@163.com
作者简介:吕楠(1982-),女,副主任医师,主要研究方向为脑发育与脑损伤。

Analysis on the therapeutic effect of L-carnitine in children with autism spectrum disorder

LÜ Nan¹, LI Dong-xiao², SHANG Qing¹, MA Cai-yun¹, LI Jing-jie¹

1 Rehabilitation Center,Children′s Hospital Affiliated to Zhengzhou University,Children′s Hospital of Henan Province, Zhengzhou Children′s Hospital,Zhengzhou,Henan 450053,China;
2 Henan Provincial Key Laboratory of Children′s Genetics and Metabolic Disease,Zhengzhou,Henan 450018,China

Received:2019-01-29 Online:2019-09-10 Published:2019-09-10
Contact: SHANG Qing,E-mail:sqing1965@163.com

摘要/Abstract

摘要： 目的分析左旋肉碱对孤独症谱系障碍(ASD)患儿的治疗效果,为ASD患儿寻求最佳治疗方案。方法 2017年9月-2018年12月选取诊断为ASD的患儿60例,随机分为治疗组和对照组各30例,对照组行常规特殊教育干预治疗,治疗组在此基础上口服左卡尼汀[100 mg/(kg·d)]。治疗前及治疗3 个月后,采用串联质谱分析检测游离肉碱含量,采用异常行为量表(ABC)、儿童孤独症评定量表(CARS)和中文版心理教育评定(C-PEP)进行量表评估。结果治疗前,两组游离肉碱均偏低,治疗3个月后,治疗组游离肉碱均有所提升[(28.28±2.26)μmol/L],对照组仍偏低[(16.54±2.08)μmol/L];治疗3个月后两组ABC总分(t_对照＝-6.32,t_治疗＝-8.05)、CARS总分(t_对照＝-1.24,t_治疗＝-1.38)较前有所降低,PEP-3 评分较前均有所提高(t_对照＝-3.584,t_治疗=-4.683),差异均有统计学意义(P<0.05);治疗组ABC总分、CARS总分及PEP-3 评分与对照组比较,差异均有统计学意义(t =-4.67,-2.43,2.884,P<0.05)。结论 ASD患者口服左卡尼汀能进一步促进认知、语言和行为方面的改善。

关键词: 孤独症谱系障碍, 左旋肉碱, 儿童

Abstract: Objective To investigate the therapeutic effect of L-carnitine on children with autism spectrum disorder(ASD),in order to find the best treatment for ASD children. Methods Totally 60 ASD children were randomly divided into treatment group(n=30) and control group(n=30) from September 2017 to December 2018. The control group was treated with routine special education intervention,and the treatment group was given levocarnitine [100 mg/(kg·d)]. Before and 3 months after treatment,the content of free carnitine was measured by tandem mass spectrometry,and was evaluated by Abnormal Behavior Scale(ABC),Child Autism Rating Scale(CARS) and Chinese Version of Psychological Education Assessment(C-PEP). Results Before treatment,free carnitine was low in both groups. After 3 months of treatment,free carnitine in the treatment group increased to(28.28±2.26)μmol/L,but it was still low in control group [(16.54 ±2.08) μmol/L]. After 3 months of treatment,the total scores of ABC(t_control=-6.32, t_treatment=-8.05),CARS(t_control=-1.24, t_treatment=-1.38) in the two groups were significantly lower than those before treatment(P＜0.05). While the score of PEP-3 was significantly higher than before in the two groups(t_control=-3.584, t_treatment=-4.683,P＜0.05).The total scores of ABC,CARS and PEP-3 were significantly different between treatment group and control group(t=-4.67,-2.43,2.884,P＜0.05). Conclusion Oral administration of L-carnitine in ASD patients can further promote cognitive,linguistic and behavioral improvements.

Key words: autism spectrum disorder, L-carnitine, children

中图分类号:

R749.94

吕楠, 李东晓, 尚清, 马彩云, 李靖婕. 左旋肉碱在儿童孤独症谱系障碍中的疗效分析[J]. 中国儿童保健杂志, 2019, 27(9): 1015-1018.

LÜ Nan, LI Dong-xiao, SHANG Qing, MA Cai-yun, LI Jing-jie. Analysis on the therapeutic effect of L-carnitine in children with autism spectrum disorder[J]. journal1, 2019, 27(9): 1015-1018.

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左旋肉碱在儿童孤独症谱系障碍中的疗效分析

Analysis on the therapeutic effect of L-carnitine in children with autism spectrum disorder

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