关键词: 先天性心脏病, 非遗传性危险因素, 病例对照研究, 新生儿

Abstract: Objective To explore the possible non-inherited risk factors of congenital heart disease(CHD) in newborn infants in Jinjiang city,so as to provide evidence for the prevention of CHD. Methods A 1∶2 matched case-control study was designed,in which 60 CHD cases were diagnosed by echocardiography in Jinjiang Municipal Hospital from January 2016 to December 2017,and 120 healthy children were selected as control group.A questionnaire survey was carried out retrospectively among parents of CHD cases and controls.Logistic regression analysis was conducted to filter suspicious risk factors of CHD in newborn infants. Results Among the 5 564 newborn infants born in Jinjiang Municipal Hospital from January 2016 to December 2017,60 CHD cases were confirmed(10.78‰) by echocardiography.Univariate Logistic regression analysis showed that the following factors were all significantly associated with CHD in newborn infants(P<0.05), including paternal alcohol consumption,maternal cold in early pregnancy, adverse pregnancy outcomes,maternal active smoking and exposure to passive smoke,accumulated time for using mobile phone,dwelling place nearby major traffic road.Multivariate Logistic regression analysis showed that high risk factors for CHD included maternal cold in early pregnancy(OR=17.84,95%CI:2.58-123.41),maternal active smoking and exposure to passive smoke in early pregnancy(OR=4.83,95%CI:1.82-12.79),paternal alcohol consumption before pregnancy(OR=6.20,95%CI:1.80-21.39),dwelling place nearby traffic road 50-100 m(OR=9.11,95%CI:2.99-27.73). Conclusions The development of CHD in newborn infants might be related to the exposure of various environmental risk factors.It is of great importance to understand those risk factors and strengthen health care in early pregnancy to prevent CHD.

Key words: congenital heart disease, non-inherited risk factors, case-control study, infant