中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (2): 215-218.DOI: 10.11852/zgetbjzz2018-1263

• 经验交流 • 上一篇    下一篇

婴儿早期维生素D水平状况及湿疹的相关性研究

邓莎莎1, 叶侃1, 沈燕2, 宋媛1   

  1. 1 苏州市立医院儿童保健科,江苏 苏州 215000;
    2 苏州大学公共卫生学院,江苏 苏州 215123
  • 收稿日期:2019-05-10 发布日期:2020-02-10 出版日期:2020-02-10
  • 通讯作者: 宋媛,E-mail:yuanyuan-sy@163.com
  • 作者简介:邓莎莎(1988-),女,江苏人,住院医师,硕士学位,研究方向为儿童生长发育与营养。
  • 基金资助:
    苏州市科技计划应用基础研究-医疗卫生指导项目(SYSD2017104)

Study on the correlation between vitamin D level and eczema in early life of infants

DENG Sha-sha1, YE Kan1, SHEN Yan2, SONG Yuan1   

  1. 1 Department of Child Health Care,Suzhou Municipal Hospital,Suzhou,Jiangsu 215000,China;
    2 School of Public Health,Medical College of Soochow University,Suzhou,Jiangsu 215123,China
  • Received:2019-05-10 Online:2020-02-10 Published:2020-02-10
  • Contact: SONG Yuan,E-mail:yuanyuan-sy@163.com

摘要: 目的 探讨婴儿早期血清25-(OH)D3水平与湿疹发病的相互关系,并为婴儿早期维生素D的补充提供参考。方法 随机抽取2016年11月-2017年10月医院体检的38~48 d龄婴儿605例,通过问卷采集基线资料,利用SCORAD评分法对湿疹进行评分,采集婴儿指尖血,采用胶体金免疫层析技术检测血清25-(OH)D3水平。结果 605例样本血清25-(OH)D3平均水平为(28.48±6.10)ng/ml,湿疹患病人数为457例(75.5%),其中421例(69.5%)为轻度,35例(5.8%)为中度,1例(0.2%)为重度。不同季节的血清25-(OH)D3水平(F=21.75,P<0.001)和湿疹发病率(χ2=16.01,P=0.014)差异均有统计学意义,其中冬季血清25-(OH)D3水平最低,但冬季湿疹的发病风险最高;而且发生在冬(Z=-2.72,调整后P=0.039)、春(Z=-3.94,调整后P<0.001)两季湿疹的SCORAD评分值均明显高于夏季。不同血清25-(OH)D3水平患儿的湿疹发病率差异无统计学意义(P>0.05),但在湿疹的严重程度上差异有统计学意义(P>0.05)。随着血清25-(OH)D3水平增加,中重度湿疹的发生风险明显增高(OR=1.063,95%CI:1.001~1.129, P=0.045);与轻度湿疹患儿相比,中重度湿疹患儿有外源性维生素D补充行为者较少(OR=0.365,95%CI:0.179~0.741,P=0.005),父母有过敏史则可增加中重度湿疹的发病风险(OR=2.857,95%CI:1.399~5.837,P=0.004)。结论 婴儿早期患有较严重湿疹者血清25-(OH)D3水平偏高,而外源性维生素D补充行为却少,该人群体内高水平25-(OH)D3的产生原因有待进一步研究。

关键词: 25-(OH)D3, 湿疹, 婴儿, 过敏性疾病

Abstract: Objective To make clear the correlation between serum 25-(OH)D3level and the development of eczema in early life of infants,so as to provide evidence for vitamin D supplementation in early infancy. Methods Totally 605 infants who took physical examination inSuzhou Municipal Hospital were recruited in this study from November 2016 to October 2017.The baseline data were collected by questionnaires survey,and SCORAD table was used to assess the severity of eczema.The level of 25-(OH)D3was tested by immune colloidal gold chromatography through blood samples collected from tip of small fingers. Results The average level of 25-(OH)D3in 605 infants was (28.48±6.10)ng/ml.Totally 457 children developed eczema(75.5%),of whom 421(65.9%) children were mild,35(5.8%) children were moderate,and one(0.2%) child developed severe eczema.The levels of 25-(OH)D3(F=21.75,P<0.001)and the incidence rate of eczema(χ2=16.01,P=0.014) in different seasons were significantly different.The level of 25-(OH)D3 was lowest in winter,but risk of eczema was highest in winter.Moreover,the SCORAD was significantly higher in spring (Z=-3.94, P<0.001) and winter (Z=-2.72,P=0.039) than that in summer.There was no significant difference on the incidence of eczema among different 25-(OH)D3 level groups,but the level of 25-(OH)D3was related to the severity of eczema.The risk of moderate to sever eczema increased with the level of 25-(OH)D3 (OR=1.063,95% CI:1.001-1.129,P=0.045),while infants with severe eczema had lower rate of vitamin D intake behavior than infants with mild eczema(OR=0.365,95%CI:0.179-0.741,P=0.005).Allergic history of parent increased the risk for severe eczema(OR=2.857,95%CI:1.399-5.837, P=0.004). Conclusion The level of 25-(OH)D3 is higher in infants with severe eczema,but those who take vitamin D supplementation are less.Further researches are warranted to explore the underlying reasons for this discrepancy.

Key words: 25-(OH)D3, eczema, infant, allergy diseases

中图分类号: