关键词: 蓝光治疗, 血清胆红素, 不良反应, Meta分析

Abstract: Objective To evaluate the efficacy and adverse reactions of different blue phototherapy modes on neonatal hyperbilirubinemia,in order to provide scientific evidence for clinical treatment. Methods The clinical randomized controlled study on the treatment of neonatal hyperbilirubinemia by blue phototherapy published from the database inception to May 2018,were retrieved in PubMed,EMBASE,Web of science,Cochrane library,CNKI,VIP and WanFang database. Most literature results were analyzed by RevMan 5.3,but some results were dealt by other medical statistics methods. Results Finally 8 literature containing 954 patients were selected. Meta-analysis showed that phototherapy can significantly decrease the infants′ serum bilirubin level (SMD=55.35,95%CI:50.23-60.48, P<0.001),of which both intermittent phototherapy and continuous phototherapy can also decrease the infants′ serum bilirubin concentration (SMD=58.72,95%CI:54.35～63.09, P<0.001;SMD=51.53,95%CI:41.48～ 61.59, P<0.001). However,the differences on cure rate of neonatal hyperbilirubinemia (χ²=0.00,P=1.00) and the decrease value of the serum bilirubin concentration (SMD=-1.24,95%CI:-5.62-3.15,P=0.58) between different blue phototherapy modes were not significant. Compared with continuous phototherapy,intermittent phototherapy showed lower rate of adverse reactions (RR=0.18,95%CI :0.13-0.25,P<0.001). Conclusions Both intermittent phototherapy and continuous phototherapy can effectively decrease the infants′ serum bilirubin concentration. Meanwhile,the intermittent phototherapy can better reduce the incidence of adverse reactions than continuous phototherapy.

Key words: blue phototherapy, bilirubin, adverse reaction, Meta-analysis