中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (5): 571-573.DOI: 10.11852/zgetbjzz2019-1709

• 临床研究与分析 • 上一篇    下一篇

改良婴幼儿孤独症量表中文简化版在3~4岁儿童中的应用分析

陈强1, 袁滨2, 徐文娟1, 戚小兵1, 杨丽勇3, 齐洋洋4   

  1. 1 珠海市妇幼保健院,广东 珠海 519001;
    2 抚州市第三医院,江西 抚州 344000;
    3 珠海高新技术产业开发区金鼎社区卫生服务中心,广东 珠海 519008;
    4 珠海市香洲区五洲幼儿园,广东 珠海 519000
  • 收稿日期:2019-11-21 发布日期:2020-05-10 出版日期:2020-05-10
  • 作者简介:陈强(1980-),男,四川人,副主任医师,硕士学位,主要研究方向为发育行为儿科学。
  • 基金资助:
    广东省医学科学技术研究基金(B2018141)

Application analysis of the Chinese simplified version of M-CHAT in children aged 3 to 4 years

CHEN Qiang1, YUAN Bin2, XU Wen-juan1, QI Xiao-bing1, YANG Li-yong3, QI Yang-yang4   

  1. 1 Zhuhai Maternal and Child Health Hospital, Zhuhai, Guangdong 519001, China;
    2 The Third Hospital of Fuzhou City, Fuzhou, Jiangxi 344000, China;
    3 Jinding Community Health Service Center, Zhuhai High Tech Industrial Development Zone, Zhuhai, Guangdong 519008, China;
    4 Wuzhou Kindergarten of Xiangzhou District, Zhuhai, Guangdong 519000, China
  • Received:2019-11-21 Online:2020-05-10 Published:2020-05-10

摘要: 目的 探索改良婴幼儿孤独症量表中文简化版(M-CHAT中文简化版)在3~4岁儿童中筛查孤独症谱系障碍(ASD)的应用价值,并制定合适界值。方法 在2018年1—12月期间,选取年龄在3~4岁之间临床诊断为ASD儿童48例及正常发育儿童96名为研究对象,对其分别进行M-CHAT中文简化版评定,并绘制ROC曲线,以评价该量表在3~4岁儿童中筛查ASD的价值。结果 M-CHAT中文简化版在3~4岁儿童中筛查ASD时,其ROC曲线下面积AUC为0.94(95%CI:0.893~0.975);当筛查界限分为13分时,M-CHAT中文简化版区别ASD和非ASD能力最高,其灵敏度为0.94(95%CI:0.828~0.987)、特异度为0.82(95%CI:0.732~0.893)、Youden指数为0.76、阳性概率比5.29(95%CI:3.400~8.200)、阴性概率比0.08(95%CI:0.030~0.200)、阳性预测值为72.58%、阴性预测值为96.34%。结论 M-CHAT中文简化版筛查3~4岁ASD儿童能力较强,值得在3~4岁年龄段儿童ASD筛查工作中推广应用。

关键词: 孤独症, M-CHAT中文简化版, 儿童

Abstract: Objective To explore the application value of Chinese simplified version of M-CHAT to screen autism spectrum disorder (ASD) in children aged 3 to 4 years,and to establish appropriate thresholds. Methods A total of 48 ASD children aged 3 to 4 years and 96 normal developing children were selected as subjects from January 2018 to December 2018. The Chinese simplified version of M-CHAT was used and ROC curve was drawn to evaluate the value of the scale in screening ASD among children aged 3 to 4 years. Results Using the Chinese simplified version of M-CHAT in screening ASD in children aged 3 to 4 years old,the area under the curve(AUC) was 0. 94 (95%CI:0. 893―0. 975). When the cutoff point was divided into 13,the Chinese simplified version of M-CHAT showed the highest ability to distinguish ASD from non-ASD. Its sensitivity was 0. 94 (95% CI:0. 828―0. 987),specificity was 0. 82 (95% CI:0. 732―0. 893),Youden index was 0. 76,positive probability ratio was 5. 29 (95% CI:3. 400-8. 200) and negative probability ratio was 0. 08 (95% CI:0. 030―0. 200). The positive predictive value was 72. 58% and the negative predictive value was 96. 34%. Conclusion The Chinese simplified version of M-CHAT shows strong ability to screen ASD children aged 3 to 4 years,and is well worth popularizing and applying in ASD screening for children aged 3 to 4 years.

Key words: autism, Chinese simplified version of M-CHAT, children

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