中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (4): 443-446.DOI: 10.11852/zgetbjzz2020-1558

• 临床研究 • 上一篇    下一篇

超重/肥胖对反复喘息婴幼儿潮气肺功能的影响

周真, 李丽云, 谭艳芳, 郭素华, 林英, 赵慧, 李增清   

  1. 广东省妇幼保健院儿科,广东 广州 511400
  • 收稿日期:2020-08-17 修回日期:2020-11-12 出版日期:2021-04-10 发布日期:2021-04-27
  • 通讯作者: 李增清,E-mail:497034441@qq.com
  • 作者简介:周真(1986-),女,湖北人,主治医师,硕士学位,主要研究方向为小儿呼吸。

Effects of overweight and obesity on tidal lung function of infants with recurrent wheezing

ZHOU Zhen, LI Li-yun, TAN Yan-fang, GUO Su-hua , LIN Ying , ZHAO Hui, LI Zeng-qing   

  1. Pediatric Department,Guangdong Women and Children Hospital,Guangzhou,Guangdong 511400,China
  • Received:2020-08-17 Revised:2020-11-12 Online:2021-04-10 Published:2021-04-27
  • Contact: LI Zeng-qing,E-mail:497034441@qq.com

摘要: 目的 分析超重/肥胖对反复喘息婴幼儿潮气肺功能的影响,为哮喘的预防和管理奠定基础。方法 选择在广东省妇幼保健院儿童呼吸科就诊的100例0~3岁反复喘息的急性发作期患儿为研究对象,按体重指数(BMI)分为喘息非超重组70例、喘息超重/肥胖组30例;选择80例0~3岁无呼吸系统疾病婴幼儿为对照组,其中非超重组50例,超重/肥胖组30例。测定各组受试患儿潮气呼吸流量-容积曲线(TBFV),记录各参数并进行比较。结果 喘息非超重组与对照非超重组比较,达峰时间比(TPTEF/TE)、达峰容积比(VPTEF/VE)、吸呼比(TI∶TE)、呼出75%潮气量时的呼气流速/呼气峰流速(25/PF)均明显下降 (t=8.518、7.767、3.142、7.860,P<0.05);呼气峰流速(PTEF)、呼出25%潮气量时的呼气流量(TEF75)显著增加(t=6.728、8.540,P<0.05)。分别在对照组、喘息组中,与非超重儿童肺功能参数相比,超重/肥胖儿童仅潮气量(VT/kg)显著下降(t=2.872、3.048,P<0.05)。结论 超重/肥胖影响婴幼儿肺功能潮气量(VT/kg),但不影响气道阻塞的指标。

关键词: 超重/肥胖, 潮气肺功能, 反复喘息, 幼儿

Abstract: Objective To investigate the effect of overweight and obesity on tidal lung function of infants with recurrent wheezing,in order to provide evidence for the prevention and control of asthma. Methods A total of 100 children aged 0 to 3 years with recurrent wheezing were selected in this study from Child Respiratory Department in Guangdong Women and Children Hospital. According to body mass index (BMI),wheezing children were divided into non-overweight group (n=70) and overweight/obesity group (n=30). And 80 children aged 0 to 3 years without respiratory diseases were selected as control group and divided into non-overweight group (n=50) and overweight/obesity group(n=30) according to BMI. The tidal breathing parameters and flow-volume loop of infants in each group were recorded and compared. Results The values oftime to peak tidal expiratory flow as a proportion of expiratory time(TPTEF/TE),volume to peak expiratory flow as a proportion of exhaled volume(VPTEF/VE),inspiratory time/expiratory time(TI∶TE),tidal expiratory flow when 25% of tidal volune remain in the lung/peak tidal expiratory flow(25/PF) of the wheezing infants with non-overweight significantly decreased compared with the control group without wheezing (t=8.518,7.767,3.142,7.860,P<0.05),while peak tidal expiratory flow(PTEF),tidal expiratory flow when 75% of tidal volume remains in the lung(TEF75) increased (t=6.728,8.540,P<0.05). In the control group and the wheezing group,compared with the non-overweight infants,tidal volume/kg(VT/kg) of infants with overweight and obesity decreased (t=2.872,3.048,P<0.05). Conclusion Overweight and obesity have impacts on VT/kg of tidal lung function,but did not affect airway obstruction indicators.

Key words: overweight and obesity, tidal lung function, recurrent wheezing, infants

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