关键词: 特应性皮炎, 脂溶性维生素, 儿童, 疾病严重程度指数

Abstract: Objective To investigate the relationship between fat-soluble vitamins (vitamin A,D,E) and the incidence and severity of atopic dermatitis (AD) in children,so as to provide theoretical reference for prevention and treatment of AD in children. Methods A total of 64 AD children diagnosed in the Second Affiliated Hospital of Hainan Medical College were selected as AD group,and 64 healthy children in the same period were recruited into control group.The severity of AD was assessed by the Scoring Atopic Dermatitis (SCORAD).The levels of vitamin A (Vit A) and vitamin E (Vit E) were tested by high performance liquid chromatography,and the level of 25-hydroxy vitamin D₃ [25(OH)D_3] was determined by liquid chromatography tandem mass spectrometry. Results Compared with control group,the AD group had significantly lower levels of Vit A and Vit E (t=3.986,4.312,P＜0.05).The mean SCORAD score of AD children was 37.8±15.3.The difference in serum 25(OH)D₃ level among mild,moderate and severe AD groups was significantly different(F=9.405, P＜0.05).Among AD children,the SCORAD score was negatively correlated with serum 25(OH)D₃ level (r=-0.389,P=0.001),but not related to Vit A and Vit E levels (P>0.05). Conclusion Vit A and Vit D deficiency or insufficiency exists in AD children,and the serum Vit D level is negatively correlated with the severity of AD.

Key words: atopic dermatitis, fat-soluble vitamin, children, disease severity index